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World J Stem Cells. Nov 26, 2014; 6(5): 598-605
Published online Nov 26, 2014. doi: 10.4252/wjsc.v6.i5.598
Published online Nov 26, 2014. doi: 10.4252/wjsc.v6.i5.598
Changes in human pluripotent stem cell gene expression after genotoxic stress exposures
Mykyta V Sokolov, Ronald D Neumann, Nuclear Medicine Division, Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD 20892, United States
Author contributions: Sokolov MV and Neumann RD contributed to this paper.
Supported by The Intramural Research Program of the National Institutes of Health, Clinical Center
Correspondence to: Mykyta V Sokolov, PhD, Nuclear Medicine Division, Department of Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, United States. sokolovm@mail.nih.gov
Telephone: +1-301-4356192 Fax: +1-301-4809712
Received: July 24, 2014
Revised: September 12, 2014
Accepted: September 17, 2014
Published online: November 26, 2014
Processing time: 66 Days and 13.8 Hours
Revised: September 12, 2014
Accepted: September 17, 2014
Published online: November 26, 2014
Processing time: 66 Days and 13.8 Hours
Core Tip
Core tip: Genome-wide alterations in gene expression in human pluripotent stem cells (hPSCs) following genotoxic stress exposures may underlie the ultimate fate and outcome of practical utility of hPSCs which makes systematic studies of these effects a high priority in stem cell research.