Randomized Clinical Trial
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World J Stem Cells. Sep 26, 2014; 6(4): 505-510
Published online Sep 26, 2014. doi: 10.4252/wjsc.v6.i4.505
Transplantation of stem cells from human exfoliated deciduous teeth for bone regeneration in the dog mandibular defect
Ali Behnia, Abbas Haghighat, Ardeshir Talebi, Nosrat Nourbakhsh, Fariba Heidari
Ali Behnia, Member of Students’ Research Center, Isfahan University of Medical Sciences, 81745-319 Isfahan, Iran
Ali Behnia, Department of Oral and Maxillofacial Surgery, Shahid Saddooghi University of Medical Sciences, Yazd Dental School, 8914881167 Yazd, Iran
Abbas Haghighat, Department of Oral and Maxillofacial Surgery, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan Dental School, 81746-73461 Isfahan, Iran
Ardeshir Talebi, Torabinejad Research Center, Department of Pathology, Faculty of Medical Sciences, Isfahan University, 81746-73461 Isfahan, Iran
Nosrat Nourbakhsh, Torabinejad Research Center, Department of Pediatric Dentistry, Isfahan University of Medical Sciences, Isfahan Dental School, 81746-73461 Isfahan, Iran
Fariba Heidari, Torabinejad Research Center, Isfahan University of Medical Sciences, Isfahan Dental School, 81746-73461 Isfahan, Iran
Author contributions: All the authors contributed equally to this manuscript.
Correspondence to: Ali Behnia, DDS, MS, Assistant Professor, Department of Oral and Maxillofacial Surgery, Shahid Saddooghi University of Medical Sciences, Yazd Dental School, 8914881167 Yazd, Iran. orod_behnia@yahoo.com
Telephone: +98-91-21792985 Fax: +98-91-21792985
Received: April 9, 2014
Revised: June 5, 2014
Accepted: July 25, 2014
Published online: September 26, 2014
Processing time: 169 Days and 5.2 Hours
Core Tip

Core tip: Stem cells from human exfoliated deciduous teeth (SHED) exist in the living pulp remnants of exfoliated deciduous teeth. The aim of this study was to investigate the effect of SHED transplanted for bone regeneration in the dog mandibular defect.In this study we found that SHEDs which had been isolated and characterized 5 years ago and stored with cryopreservation banking were capable of proliferation and osteogenesis after 5 years, and no immune response was observed after three months of seeded SHEDs.