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World J Stem Cells. Sep 26, 2014; 6(4): 421-431
Published online Sep 26, 2014. doi: 10.4252/wjsc.v6.i4.421
Published online Sep 26, 2014. doi: 10.4252/wjsc.v6.i4.421
Early B lymphocyte development: Similarities and differences in human and mouse
Michiko Ichii, Kenji Oritani, Yuzuru Kanakura, Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan
Author contributions: Ichii M, Oritani K and Kanakura Y contributed to this paper.
Correspondence to: Kenji Oritani, MD, Department of Hematology and Oncology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan. oritani@bldon.med.osaka-u.ac.jp
Telephone: +81-6-68793871 Fax: +81-6-68793879
Received: July 25, 2014
Revised: August 29, 2014
Accepted: September 4, 2014
Published online: September 26, 2014
Processing time: 61 Days and 18.6 Hours
Revised: August 29, 2014
Accepted: September 4, 2014
Published online: September 26, 2014
Processing time: 61 Days and 18.6 Hours
Core Tip
Core tip: There are several species differences between human and mouse, while the mouse studies precede those of human. Recent progresses of experimental techniques have made it possible to understand the biology in human B lymphopoiesis deeply. Various phenotype markers, which can define the distinct developmental stages, and requirement of cytokines are distinguishable. More common issues are observed in the role of signaling molecules, including transforming growth factor-β superfamily, Wnt family, and Notch family, which have been known the high conservation among mammals. The knowledge on niches for human hematopoietic stem cell and B cell development is still limited.