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©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Stem Cells. Oct 26, 2013; 5(4): 229-237
Published online Oct 26, 2013. doi: 10.4252/wjsc.v5.i4.229
Published online Oct 26, 2013. doi: 10.4252/wjsc.v5.i4.229
Neural stem cells isolated from amyloid precursor protein-mutated mice for drug discovery
Vito Antonio Baldassarro, Giulia Lizzo, Mercedez Fernández, Health Science and Technologies Interdepartmental Center for Industrial Research (HST-ICIR), I-40064 Ozzano Emilia, Bologna, Italy
Michela Paradisi, Department of Veterinary Medicine, University of Bologna, I-40064 Ozzano Emilia, Bologna, Italy
Luciana Giardino, Laura Calzà, Health Science and Technologies Interdepartmental Centre for Industrial Research (HST-ICIR) and IRET Foundation, I-40064 Ozzano Emilia, Bologna, Italy
Giulia Lizzo, Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy-Sur-Seine, Yvelines, France
Author contributions: Baldassarro VA wrote the manuscript and performed part of the experiments; Lizzo G and Paradisi M performed the majority of the experiments; Fernandez M set up the techniques and contributed to the manuscript; Giardino L and Calzà L designed the study and revised the manuscript.
Supported by Regione Emilia Romagna, POR-FESR 2011-2014
Correspondence to: Laura Calzà, MD, Health Science and Technologies Interdepartmental Centre for Industrial Research (HST-ICIR), University of Bologna, Via Tolara di Sopra 41/E, I-40064 Ozzano Emilia, Bologna, Italy. laura.calza@unibo.it
Telephone: +39-51-798776 Fax: +39-51-799673
Received: June 24, 2013
Revised: October 4, 2013
Accepted: October 17, 2013
Published online: October 26, 2013
Processing time: 128 Days and 18.1 Hours
Revised: October 4, 2013
Accepted: October 17, 2013
Published online: October 26, 2013
Processing time: 128 Days and 18.1 Hours
Core Tip
Core tip: In this study neural stem cells isolated from Tg2576 mice are characterized as an in vitro model for Alzheimer’s disease. These cells represent a robust system for studying pathological mechanisms related to Aβ intracellular accumulation, such as stem cell status, or during differentiation processes. This model could provide a new cell platform for developing and screening new molecules.