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World J Stem Cells. Oct 26, 2013; 5(4): 196-204
Published online Oct 26, 2013. doi: 10.4252/wjsc.v5.i4.196
Published online Oct 26, 2013. doi: 10.4252/wjsc.v5.i4.196
Mobilization of CD34+CD38- hematopoietic stem cells after priming in acute myeloid leukemia
Adriana Plesa, Eve Mattei, Charles Dumontet, Laboratoire de Cytologie et d’Immunologie, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, 69495 Pierre Bénite, France
Youcef Chelghoum, Hélène Labussière, Giovanna Cannas, Mauricette Michallet, Xavier Thomas, Department of Hematology, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, 69495 Pierre Bénite, France
Mohamed Elhamri, Stéphane Morisset, Unité de Recherche Clinique, Service d’Hématologie, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, 69495 Pierre Bénite, France
Inès Tagoug, INSERM U590, Laboratoire de Cytologie Analytique, Faculté de Médecine Rockefeller, Université Lyon-I, 69495 Lyon, France
Author contributions: Plesa A was responsible for co-ordinating immunophenotyping data and participated in the analysis and interpretation of data; Mattei E and Tagoug I participated in the collection of immunophenotyping data; Morisset S performed statistical analyses; Chelghoum Y, Labussière H and Cannas G included patients and collected samples; Elhamri M collected the data and provided technical support; Michallet M and Dumontet C reviewed the manuscript and gave final approval; Thomas X included patients, collected samples, interpreted the data and wrote the manuscript.
Correspondence to: Xavier Thomas, MD, PhD, Department of Hematology, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Pavillon Marcel Bérard, Bât.1G, 165 chemin du Grand Revoyet, 69495 Pierre Bénite, France. xavier.thomas@chu-lyon.fr
Telephone: +33-478862235 Fax: +33-472678880
Received: May 2, 2013
Revised: June 23, 2013
Accepted: July 30, 2013
Published online: October 26, 2013
Revised: June 23, 2013
Accepted: July 30, 2013
Published online: October 26, 2013
Core Tip
Core tip: Timed sequential chemotherapy and priming with hematopoietic growth factors have been recently used in the treatment of acute myeloid leukemia in order to mobilize more leukemic cells in the cell cycle and therefore improve the cytotoxic effect of chemotherapy. In this paper, we looked the impact of this type of treatment in a small series of patients on the mobilization of different subsets of CD34+ cells involving “bulk” leukemic cells and more ‘‘immature’’ leukemic cells.