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©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Stem Cells. Oct 26, 2013; 5(4): 188-195
Published online Oct 26, 2013. doi: 10.4252/wjsc.v5.i4.188
Published online Oct 26, 2013. doi: 10.4252/wjsc.v5.i4.188
Epithelial-mesenchymal transition - activating transcription factors - multifunctional regulators in cancer
Minal Garg, Department of Biochemistry, University of Lucknow, Lucknow, UP 226007, India
Author contributions: Garg M solely contributed to this paper.
Correspondence to: Minal Garg, PhD, Assistant Professor, Department of Biochemistry,University of Lucknow, Lucknow, UP 226007, India. minal14@yahoo.com
Telephone: +91-522-2348968
Received: May 17, 2013
Revised: July 6, 2013
Accepted: September 4, 2013
Published online: October 26, 2013
Revised: July 6, 2013
Accepted: September 4, 2013
Published online: October 26, 2013
Core Tip
Core tip: This review article discusses the mechanistic regulation of embryonic signaling pathways with a special focus on epithelial mesenchymal transition (EMT)-activating transcription factors in cancer progression via modulating the process of EMT. Deciphering this mechanism may lead to the design of cancer therapies by altering the balance between the process of EMT/mesenchymal epithelial transition in cancer stem cells and thereby clinically treat the cancer.