Therapeutic potential of stem cell-derived exosomes in hair regeneration: A systematic review

doi:10.4252/wjsc.v17.i7.108519

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Jul 26, 2025 (publication date) through Jul 27, 2025

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Systematic Reviews

World J Stem Cells. Jul 26, 2025; 17(7): 108519
Published online Jul 26, 2025. doi: 10.4252/wjsc.v17.i7.108519

Therapeutic potential of stem cell-derived exosomes in hair regeneration: A systematic review

Neil Poddar, Adarsh Aratikatla, Ashim Gupta

Neil Poddar, Medical School, Albany Medical College, Albany, NY 12208, United States

Adarsh Aratikatla, Medical School, The Royal College of Surgeons in Ireland, Dublin D02 YN77, Ireland

Ashim Gupta, Department of Orthopaedics and Regenerative Medicine, Future Biologics, Lawrenceville, GA 30043, United States

Author contributions: Poddar N, Aratikatla A, and Gupta A drafted, critically reviewed and edited the manuscript; Gupta A conceptualized and supervised the study; all authors approved the final version of the article for publication.

Conflict-of-interest statement: The authors report no relevant conflicts of interest for this article.

PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Ashim Gupta, MS, PhD, MBA, DABRM, FABRM, CEO, Professor, Department of Orthopaedics and Regenerative Medicine, Future Biologics, 2505 Newpoint Pkwy, Lawrenceville, GA 30043, United States. ashim6786@gmail.com

Received: April 16, 2025
Revised: May 27, 2025
Accepted: June 16, 2025
Published online: July 26, 2025
Processing time: 99 Days and 15 Hours

Core Tip

Core Tip: This review synthesizes findings from in vitro, preclinical, and clinical studies to evaluate the efficacy, mechanisms, and challenges associated with exosome-based hair restoration therapies. A total of 27 studies met the pre-defined search and inclusion criteria and were included in this review. Exosome-based therapies hold immense promise for hair regeneration by leveraging their ability to modulate key signaling pathways and enhance hair follicle regeneration. While in vitro and preclinical studies demonstrate consistent efficacy across diverse exosome sources, methodological heterogeneity and limited number of clinical studies warrant further clinical research to realize their full clinical potential for hair regeneration.