Sengul Bag F, Bag OF. Molecular and therapeutic effects of mesenchymal stem cell-derived exosomes on autoimmune diseases. World J Stem Cells 2025; 17(7): 107202 [DOI: 10.4252/wjsc.v17.i7.107202]
Corresponding Author of This Article
Fatma Sengul Bag, PhD, Assistant Professor, Department of Biochemistry, Adıyaman University Faculty of Pharmacy, Central Classroom C Block, 3 Floor, Adıyaman 02040, Türkiye. fatmasengul245@gmail.com
Research Domain of This Article
Biochemistry & Molecular Biology
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Stem Cells. Jul 26, 2025; 17(7): 107202 Published online Jul 26, 2025. doi: 10.4252/wjsc.v17.i7.107202
Molecular and therapeutic effects of mesenchymal stem cell-derived exosomes on autoimmune diseases
Fatma Sengul Bag, Omer Faruk Bag
Fatma Sengul Bag, Department of Biochemistry, Adıyaman University Faculty of Pharmacy, Adıyaman 02040, Türkiye
Omer Faruk Bag, Adiyaman Training and Research Hospital, Adıyaman 02040, Türkiye
Author contributions: Sengul Bag F and Bag OF reviewed and revised the manuscript and approved the final submitted manuscript.
Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fatma Sengul Bag, PhD, Assistant Professor, Department of Biochemistry, Adıyaman University Faculty of Pharmacy, Central Classroom C Block, 3 Floor, Adıyaman 02040, Türkiye. fatmasengul245@gmail.com
Received: March 18, 2025 Revised: April 3, 2025 Accepted: June 4, 2025 Published online: July 26, 2025 Processing time: 128 Days and 19.9 Hours
Core Tip
Core Tip: Autoimmune diseases result from dysregulated immune responses directed against self-antigens, leading to chronic inflammation and tissue damage. Mesenchymal stem cells (MSCs) and MSC-derived exosomes have demonstrated significant potential as therapeutic agents due to their strong immunomodulatory and regenerative properties. MSC-derived exosomes modulate immune responses by regulating cytokine secretion, suppressing inflammatory cell activity, and promoting immune tolerance. Their advantages, including low immunogenicity and the ability to cross biological barriers, make them a promising cell-free therapy for autoimmune. Even though preclinical and clinical findings are encouraging, further research is required to standardize protocols, optimize therapeutic efficacy, and ensure long-term safety.
