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World J Stem Cells. Jul 26, 2025; 17(7): 107080
Published online Jul 26, 2025. doi: 10.4252/wjsc.v17.i7.107080
Engineering the future of nanomedicine: Strategic approaches to extracellular vesicle-based drug administration regimens
Yuan-Long Ye, Lei Liu
Yuan-Long Ye, Lei Liu, State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Ye YL contributed to the literature review, drafting, and writing of this paper; Liu L contributed to the revision and editing of the manuscript, and gave approval to the final version.
Supported by the Natural Science Foundation of Sichuan Province, No. 24NSFSC0679; and State Key Clinical Department of Oral & Maxillofacial Surgery.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lei Liu, Doctor, Professor, State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd Section of Renminnan Road, Chengdu 610041, Sichuan Province, China. liulei@scu.edu.cn
Received: March 16, 2025
Revised: April 21, 2025
Accepted: June 19, 2025
Published online: July 26, 2025
Processing time: 131 Days and 23.3 Hours
Core Tip

Core Tip: This review summarizes the latest drug delivery strategies involving extracellular vesicles, focusing on systemic and local applications. It introduces various engineering approaches, administration strategies, and auxiliary delivery systems. Finally, the review discusses existing challenges in extracellular vesicle-based drug delivery and provides insights into the trends for future development in this field.