Differentiation of patient-specific induced pluripotent stem cells derived from type 1 diabetes peripheral blood mononuclear cells into pancreatic β-like cells
Kun Wang, Wei Lin, Jun-Yong Han, Jin-Yan Chen, Rong-Hua Liu, Zhen Yu, Jing-Jun Jin
Kun Wang, Jun-Yong Han, Jin-Yan Chen, Rong-Hua Liu, Zhen Yu, Jing-Jun Jin, Fujian Key Laboratory of Medical Analysis, Fujian Academy of Medical Sciences, Fuzhou 350001, Fujian Province, China
Wei Lin, Department of Endocrinology, Shengli Clinical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital, Fuzhou 350001, Fujian Province, China
Author contributions: Wang K and Lin W conceived of the project and wrote the manuscript; Han JY, Chen JY, and Jin JJ also contributed to study conception and design; Lin W performed sample collection and analysis; Wang K, Han JY, Liu RH, and Yu Z performed material preparation, data analysis, and conducted most of the experiments; Chen JY and Jin JJ provided critical discussions and advice; Wang K and Han JY edited the manuscript. All authors have read and agreed to the published version of the manuscript.
Supported by the Nonprofit Research Institutes Foundation of Fujian Province, China, No. 2020R1011003 and No. 2022R1012001; and the Talents Training Project for the Key Young Scholars of Fujian Provincial Health Commission, China, No. 2021GGA056.
Institutional review board statement: The study was reviewed and approved by the Ethics Committee of Fujian Provincial Hospital (approval number: K2021 04 020).
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Ethics Committee of Fujian Academy of Medical Sciences (approval number: DL2021-05).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Kun Wang, PhD, Associate Professor, Fujian Key Laboratory of Medical Analysis, Fujian Academy of Medical Sciences, No. 7 Wusi Road, Fuzhou 350001, Fujian Province, China.
wangkun973@fjms.ac.cn
Received: December 28, 2024
Revised: March 26, 2025
Accepted: June 18, 2025
Published online: July 26, 2025
Processing time: 210 Days and 0.1 Hours
