Letter to the Editor
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. May 26, 2025; 17(5): 107078
Published online May 26, 2025. doi: 10.4252/wjsc.v17.i5.107078
Potential of mesenchymal stem cell-derived exosomes in the treatment of androgenetic alopecia
Ramya Lakshmi Rajendran, Byeong-Cheol Ahn, Prakash Gangadaran
Ramya Lakshmi Rajendran, Byeong-Cheol Ahn, BK21 FOUR KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents, Department of Biomedical Sciences, School of Medicine, Kyungpook National University, Daegu 41944, South Korea
Ramya Lakshmi Rajendran, Byeong-Cheol Ahn, Prakash Gangadaran, Department of Nuclear Medicine, School of Medicine, Kyungpook National University, Daegu 41944, South Korea
Ramya Lakshmi Rajendran, Byeong-Cheol Ahn, Prakash Gangadaran, Cardiovascular Research Institute, Kyungpook National University, Daegu 41944, South Korea
Byeong-Cheol Ahn, Department of Nuclear Medicine, Kyungpook National University Hospital, Daegu 41944, South Korea
Co-corresponding authors: Byeong-Cheol Ahn and Prakash Gangadaran.
Author contributions: Rajendran RL, Ahn BC, and Gangadaran P designed the overall concept and outline of the manuscript, contributed to the discussion and design of the manuscript, and contributed to the writing and editing of the manuscript, illustrations, and review of the literature. Ahn BC and Gangadaran P served as co–corresponding authors and contributed equally to the supervision, critical revision, and final approval of the manuscript.
Supported by Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education, No. NRF-2022R1I1A1A01068652.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Prakash Gangadaran, Research Assistant Professor, Department of Nuclear Medicine, School of Medicine, Kyungpook National University, No. 680 Gukchaebosang ro, Jung gu, Daegu 41944, South Korea. prakashg@knu.ac.kr
Received: March 16, 2025
Revised: April 3, 2025
Accepted: May 7, 2025
Published online: May 26, 2025
Processing time: 71 Days and 13.9 Hours
Core Tip

Core Tip: Alopecia areata is an autoimmune disorder that promotes hair loss. Fu et al have demonstrated that exosomes derived from human adipose-derived mesenchymal stem cells stimulate hair follicle regeneration by activating the Wnt/β-catenin signaling pathway through cell division cycle protein 42. The study by Fu et al underscores the potential of exosome-based therapies as a promising, cell-free approach for treating androgenetic alopecia, thereby advancing regenerative medicine in hair restoration.