Aberrant bone formation and dysregulated bone homeostasis in ankylosing spondylitis

doi:10.4252/wjsc.v17.i5.106934

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 17, Issue 5

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (85)

All Articles published online

The chart showing PDF series, HTML series, Tables (1-1) series.

Item

Count

PDF

HTML

Tables (1-1)

Sum=56

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

Download

Sum=24

May 26, 2025 (publication date) through May 29, 2025

Times Cited of This Article

Times Cited (0)

Journal Information of This Article

Publication Name

World Journal of Stem Cells

ISSN

1948-0210

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Editorial

World J Stem Cells. May 26, 2025; 17(5): 106934
Published online May 26, 2025. doi: 10.4252/wjsc.v17.i5.106934

Aberrant bone formation and dysregulated bone homeostasis in ankylosing spondylitis

Gun Woo Lee

Gun Woo Lee, Department of Orthopedic Surgery, Yeungnam University College of Medicine, Daegu 42415, South Korea

Gun Woo Lee, Institute for Quantitative Health Science & Engineering, East Lansing, MI 48824, United States

Author contributions: Lee GW wrote, revised the manuscript, and approved the final manuscript published.

Supported by 2024 Yeungnam University Research Grant.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Gun Woo Lee, MD, PhD, Associate Professor, Department of Orthopedic Surgery, Yeungnam University College of Medicine, No. 170 Hyunchung-ro, Namgu, Daegu 42415, South Korea. gwlee1871@gmail.com

Received: March 11, 2025
Revised: April 3, 2025
Accepted: May 7, 2025
Published online: May 26, 2025
Processing time: 76 Days and 17.4 Hours

Core Tip

Core Tip: In ankylosing spondylitis (AS), osteoclasts contribute significantly to pathological bone resorption and remodeling. The receptor activator of nuclear factor-kappa B/receptor activator of nuclear factor-kappa B ligand/osteoprotegerin signaling axis, inflammatory cytokines such as interleukin-17 and tumor necrosis factor-alpha, and immune cells such as T helper type 17 and macrophages are central to osteoclastogenesis in AS. Elucidation of the mechanisms governing osteoclast differentiation, activation, and dysregulation in AS is essential for the development of targeted therapeutic strategies that modulate aberrant bone remodeling.