Mechanisms and challenges of mesenchymal stem cells in the treatment of knee osteoarthritis

doi:10.4252/wjsc.v17.i4.102923

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Apr 26, 2025 (publication date) through Apr 23, 2025

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Apr 26, 2025; 17(4): 102923
Published online Apr 26, 2025. doi: 10.4252/wjsc.v17.i4.102923

Mechanisms and challenges of mesenchymal stem cells in the treatment of knee osteoarthritis

Jing-Shun Lu, Chen-Yu Song, Wen-Jing Cheng, Kai-Yang Wang

Jing-Shun Lu, Wen-Jing Cheng, Department of Orthopedics, The First Affiliated Hospital of Wannan Medical College, Yijishan Hospital, Wuhu 241000, Anhui Province, China

Chen-Yu Song, Kai-Yang Wang, Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China

Author contributions: Lu JS wrote and edited the manuscript; Song CY and Cheng WJ contributed to review and editing; Wang KY conceived, reviewed, and revised the manuscript.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Kai-Yang Wang, MD, Assistant Professor, Department of Orthopedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, No. 600 Yishan Road, Shanghai 200233, China. ortho_wang@163.com

Received: November 4, 2024
Revised: February 22, 2025
Accepted: March 21, 2025
Published online: April 26, 2025
Processing time: 172 Days and 11 Hours

Core Tip

Core Tip: Mesenchymal stem cells (MSCs) exhibit remarkable efficacy in the field of regenerative medicine and are considered to be the key cells for the repair and regeneration of cartilage. In this paper, we explore the clinical application of MSCs in the treatment of osteoarthritis and address the challenges associated with MSC therapy.