Hypoxic endometrial epithelial cell-derived microRNAs effectively regulate the regenerative properties of mesenchymal stromal cells

doi:10.4252/wjsc.v17.i4.102482

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Apr 26, 2025 (publication date) through Apr 23, 2025

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Letter to the Editor

World J Stem Cells. Apr 26, 2025; 17(4): 102482
Published online Apr 26, 2025. doi: 10.4252/wjsc.v17.i4.102482

Hypoxic endometrial epithelial cell-derived microRNAs effectively regulate the regenerative properties of mesenchymal stromal cells

Panagiotis Mallis

Panagiotis Mallis, Hellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, Athens 11527, Attikí, Greece

Author contributions: Mallis P wrote and revised the manuscript.

Conflict-of-interest statement: The author reports no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Panagiotis Mallis, PhD, Postdoctoral Fellow, Hellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, 4 Soranou Ephessiou Street, Athens 11527, Attikí, Greece. pmallis@bioacademy.gr

Received: October 21, 2024
Revised: February 6, 2025
Accepted: March 5, 2025
Published online: April 26, 2025
Processing time: 186 Days and 6.9 Hours

Core Tip

Core Tip: Endometrial tissue damage is the primary reason for unsuccessful embryo implantation. Hypoxic damaged endometrial epithelial cells can secrete miRNAs through exosomes, which can efficiently regulate endometrial microenvironment homeostasis. Specifically, miR-21-5p and miR-214-5p can regulate the migration, wound healing and differentiation of umbilical cord-derived mesenchymal stromal cells. Therefore, the latter favors endometrial tissue regeneration. By understanding the primary endometrial defect, alternative therapeutic protocols such as advanced cellular therapies may be used to restore women’s fertility.