Evaluating the efficacy of stem cells in treating severe dry eye disease

doi:10.4252/wjsc.v17.i4.101891

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Apr 26, 2025 (publication date) through Apr 23, 2025

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Apr 26, 2025; 17(4): 101891
Published online Apr 26, 2025. doi: 10.4252/wjsc.v17.i4.101891

Evaluating the efficacy of stem cells in treating severe dry eye disease

Lanxing Fu, Lucia Pelosini, Nick Kopsachilis, Roberta Foti, Fabiana D’Esposito, Mutali Musa, Alberto D’Amico, Daniele Tognetto, Caterina Gagliano, Marco Zeppieri

Lanxing Fu, Nick Kopsachilis, Department of Ophthalmology, East Kent Hospitals University NHS Foundation Trust, Canterbury CT1 3NG, United Kingdom

Lucia Pelosini, Department of Ophthalmology, King’s College Hospital NHS Foundation Trust, London SE5 9RS, United Kingdom

Roberta Foti, Division of Rheumatology, A.O.U. “Policlinico-San Marco,” Catania 95123, Italy

Fabiana D’Esposito, Imperial College Ophthalmic Research Group Unit, Imperial College, London NW1 5QH, United Kingdom

Fabiana D’Esposito, Department of Neurosciences, Reproductive Sciences and Dentistry, University of Naples Federico II, Via Pansini 5, 80131 Napoli, Italy.

Mutali Musa, Department of Optometry, University of Benin, Benin 300283, Nigeria

Mutali Musa, Department of Ophthalmology, Centre for Sight Africa, Nkpor, Onitsha 434112, Nigeria

Alberto D’Amico, Academic Neurosurgery, Department of Neurosciences, University of Padova, Padova 35128, Italy

Daniele Tognetto, Marco Zeppieri, Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste 34129, Italy

Caterina Gagliano, Department of Medicine and Surgery, University of Enna “Kore,” Catania 94100, Italy

Caterina Gagliano, Mediterranean Foundation "G.B. Morgagni", 95125 Catania, Italy.

Marco Zeppieri, Department of Ophthalmology, University Hospital of Udine, Udine 33100, Italy

Co-corresponding authors: Caterina Gagliano and Marco Zeppieri.

Author contributions: Fu L contributed to the research, drafting, writing the paper, and providing the final approval of the article; Pelosini L, Kopsachilis N, Foti R, D’Esposito F, Musa M, D’Amico A, Tognetto D, and Gagliano C assisted in the research and the editing and writing of the manuscript; Zeppieri M assisted in the design of the study, writing, outlining, providing the final approval of the version of the article to be published, and completing the English and scientific editing. Zeppieri M and Gagliano C participated equally and share the corresponding authorship.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Marco Zeppieri, BSc, MD, PhD, Doctor, Department of Ophthalmology, University Hospital of Udine, p.le S. Maria della Misericordia 15, Udine 33100, Italy. mark.zeppieri@asufc.sanita.fvg.it

Received: September 29, 2024
Revised: February 17, 2025
Accepted: March 21, 2025
Published online: April 26, 2025
Processing time: 205 Days and 5.6 Hours

Core Tip

Core Tip: Stem cell treatment offers a potential regenerative strategy for addressing severe dry eye disease by restoring lacrimal gland function, regulating inflammation, and facilitating corneal restoration. This review incorporated current preclinical and clinical discoveries, contrasting various mesenchymal stem cell (MSC) sources and their modes of action. Notwithstanding promising outcomes, obstacles persist in enhancing MSC viability, standardizing administration techniques, and guaranteeing prolonged safety. More extensive randomized controlled studies are necessary to determine the effectiveness of MSC-based treatments in severe dry eye disease.