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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Mar 26, 2025; 17(3): 103360
Published online Mar 26, 2025. doi: 10.4252/wjsc.v17.i3.103360
Published online Mar 26, 2025. doi: 10.4252/wjsc.v17.i3.103360
Emerging role of mesenchymal stem cell-derived exosomes in the repair of acute kidney injury
Juan-Juan Wang, Yu Zheng, Yan-Lin Li, Clinical Laboratory, The First People’s Hospital of Yancheng, Yancheng First Hospital, Affiliated Hospital of Nanjing University Medical School, Yancheng 224000, Jiangsu Province, China
Yin Xiao, Department of Medical Imaging, The Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China
Yang-Yang Ren, Clinical Laboratory, Xinyi People’s Hospital, Xuzhou 221000, Jiangsu Province, China
Yi-Qing Tian, Clinical Laboratory, Xuzhou Central Hospital, Xuzhou 221000, Jiangsu Province, China
Co-first authors: Juan-Juan Wang and Yu Zheng.
Co-corresponding authors: Yang-Yang Ren and Yi-Qing Tian.
Author contributions: Wang JJ and Zheng Y drafted the initial manuscript and contributed equally to this manuscript as co-first authors; Li YL and Xiao Y contributed to the figure and table artwork and illustrations; Ren YY and Tian YQ conceptualized and designed the review and contributed equally to this manuscript as co-corresponding authors. All authors critically reviewed the manuscript for important intellectual content, approved the final manuscript as submitted, and agreed to be accountable for work.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yi-Qing Tian, Dr, Clinical Laboratory, Xuzhou Central Hospital, No. 199 Jiefang South Road, Xuzhou 221000, Jiangsu Province, China. 824303893@qq.com
Received: November 18, 2024
Revised: December 26, 2024
Accepted: February 13, 2025
Published online: March 26, 2025
Processing time: 124 Days and 18.2 Hours
Revised: December 26, 2024
Accepted: February 13, 2025
Published online: March 26, 2025
Processing time: 124 Days and 18.2 Hours
Core Tip
Core Tip: Exosomes secreted by mesenchymal stem cells are increasingly recognized for their small size, lack of cellular components, stability, enhanced biocompatibility, and reduced toxicity. In studies of experimental acute kidney injury, exosomes have shown great potential in terms of their safety and efficacy as well as their ability to modulate gene expression and transcription in recipient cells.