Copyright
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Feb 26, 2025; 17(2): 99132
Published online Feb 26, 2025. doi: 10.4252/wjsc.v17.i2.99132
Published online Feb 26, 2025. doi: 10.4252/wjsc.v17.i2.99132
WDR36 inhibits the osteogenic differentiation and migration of periodontal ligament stem cells
Yi Wang, Department of Wangfujing General School of Stomatology, Capital Medical University, Beijing 100070, China
Feng-Qiu Zhang, Department of Periodontics School of Stomatology, Capital Medical University, Beijing 100070, China
Zhi-Peng Fan, Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Stomatological Hospital, School of Stomatology, Beijing 100070, China
Zhi-Peng Fan, Beijing Laboratory of Oral Health, Capital Medical University, Beijing 100070, China
Zhi-Peng Fan, Research Unit of Tooth Development and Regeneration, Chinese Academy of Medical Sciences, Beijing 100070, China
Xin-Ling Zhu, Department of Periodontology, Hangzhou Stomatology Hospital, Hangzhou 310006, Zhejiang Province, China
Wan-Hao Yan, Laboratory of Molecular Signaling and Stem Cells Therapy, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing 100070, China
Xiu-Li Zhang, Department of Stomatology, Civil Aviation General Hospital, Beijing 100123, China
Co-corresponding authors: Feng-Qiu Zhang and Zhi-Peng Fan.
Author contributions: Wang Y wrote the manuscript; Zhang FQ and Fan ZP conceptualized the study, revised and formatted the content of the manuscript, and verified spelling, punctuation, and grammatical errors; Wang Y, Zhu XL, Yan WH, and Zhang XL carried out the experiments and analyzed the data. The collaboration between Zhang FQ and Fan ZP was essential for the publication of this manuscript. Both authors contributed equally to the research, including study design, revised and formatted the content of the manuscript, and verified spelling, punctuation, and grammatical errors. This statement confirms that both Zhang FQ and Fan ZP share equal responsibility and contribution as co-corresponding authors of this work. All authors contributed to the preparation of the manuscript.
Supported by Beijing Natural Science Foundation, No. 7192076.
Institutional review board statement: Institutional review board approval was not needed for this study because the cells used in this study were commercially obtained from LMAI Bio Company (Shanghai, China), which complies with all relevant ethical guidelines for cell procurement and distribution. These cells were further modified by surface marking in our laboratory for the purposes of this research. As no human or animal subjects were involved in the collection of the cells used, no additional ethical approval was required.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Data sharing statement: The datasets generated during the current work are available from the corresponding authors on reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Feng-Qiu Zhang, Department of Periodontics School of Stomatology, Capital Medical University, No. 9 Fanjiacun Road, Fengtai District, Beijing 100070, China. zhfengqiu@126.com
Received: July 23, 2024
Revised: November 23, 2024
Accepted: January 16, 2025
Published online: February 26, 2025
Processing time: 215 Days and 18.3 Hours
Revised: November 23, 2024
Accepted: January 16, 2025
Published online: February 26, 2025
Processing time: 215 Days and 18.3 Hours
Core Tip
Core Tip: Periodontal ligament stem cells (PDLSCs) are an important cell source for periodontal tissue regeneration. They can migrate to injured areas to promote tissue repair, induce osteogenic differentiation for bone tissue regeneration, and delay tissue loss by inhibiting senescence. In this study, we investigated the regulatory function of WD repeat-containing protein 36 (WDR36) on PDLSCs and found that WDR36 inhibited the migration, osteogenic differentiation, and senescence of PDLSCs. Thus, WDR36 may serve as a new candidate target for periodontal tissue regeneration.