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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Feb 26, 2025; 17(2): 96893
Published online Feb 26, 2025. doi: 10.4252/wjsc.v17.i2.96893
Published online Feb 26, 2025. doi: 10.4252/wjsc.v17.i2.96893
Nicotinamide adenine dinucleotide rejuvenates septic bone marrow mesenchymal stem cells
Xin Xia, Kun Zhou, Lin-Ying An, Min Zhao, Yin Tong, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China
Bin-Le Tian, Cancer Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China
Jin-Yan Zhao, Department of Laboratory Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China
Zhi-Gang Zhou, Department of Critical Care Medicine, School of Medicine, Shanghai Jiao Tong University, Shanghai 201620, China
Co-first authors: Xin Xia and Kun Zhou.
Co-corresponding authors: Zhi-Gang Zhou and Yin Tong.
Author contributions: Zhou ZG and Tong Y contributed to the funding acquisition, writing - review & editing and supervision of this manuscript, they contributed equally to this manuscript as co-corresponding authors; Xia X and Zhou K took part in the investigation and visualization, manuscript writing - original draft, they contributed equally to this manuscript as co-first authors; An LY and Zhao M participated in collect samples; Tian BL contributed to the data visualization and interpretation of this manuscript; An LY, Zhao M, and Zhao JY participated in the resources of this study.
Supported by Shanghai Natural Science Foundation, No. 21ZR1452300; and the Clinical Research Innovation Plan of Shanghai General Hospital, No. CCTR-2022B04.
Institutional review board statement: This study was approved by the institutional review board of Shanghai General Hospital, No. [2023]145.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data were available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yin Tong, PhD, Professor, Department of Hematology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No. 100 Haining Road, Shanghai 200080, China. 18616909158@163.com
Received: May 17, 2024
Revised: November 19, 2024
Accepted: January 16, 2025
Published online: February 26, 2025
Processing time: 282 Days and 20.4 Hours
Revised: November 19, 2024
Accepted: January 16, 2025
Published online: February 26, 2025
Processing time: 282 Days and 20.4 Hours
Core Tip
Core Tip: Sepsis often leads to multiorgan dysfunction, including damage to bone marrow mesenchymal stem cells (BMSCs). This damage accelerates the aging of BMSCs, resulting in impaired self-renewal and differentiation abilities and weakened hematopoietic support functions. These changes disrupt hematopoiesis and may even cause long-term immunosuppression and bone loss. Nicotinamide adenine dinucleotide, which protects mitochondrial function, can rejuvenate septic BMSCs and provide a new target for adjunctive therapy to control post-sepsis complications.