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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Feb 26, 2025; 17(2): 102091
Published online Feb 26, 2025. doi: 10.4252/wjsc.v17.i2.102091
Published online Feb 26, 2025. doi: 10.4252/wjsc.v17.i2.102091
Effect of adipose-derived stem cells exosomes cross-linked chitosan-αβ-glycerophosphate thermosensitive hydrogel on deep burn wounds
Lei Xu, Hai-Long Yun, Department of Pathology, General Hospital of the Western Theater Command, Chengdu 610038, Sichuan Province, China
Dan Liu, Wei Zhang, Li Ren, Wen-Wen Li, Chuan Han, Department of Endocrinology, General Hospital of the Western Theater Command, Chengdu 610038, Sichuan Province, China
Co-first authors: Lei Xu and Dan Liu.
Author contributions: Xu L and Liu D contributed equally to this study and as co-first authors. Xu L, Liu D, Zhang W, Ren L, Li WW, and Han C contributed to manuscript writing; Xu L and Yun HL were responsible for the preparation of figures; and all authors participated in the manuscript review.
Supported by the Incubation Program of the General Hospital of the Western Theater Command, No. 2021-XZYG-C29 and No. 2021-XZYG-B32.
Institutional animal care and use committee statement: The animal care and experimental protocols were approved by the Institutional Animal Care and Use Committee of the General Hospital of the Western Theater Command (Approval Number: XBZQZYY2021-046). The study was designed to minimize animal distress, and all rats were humanely euthanized using an overdose of barbiturate through intravenous injection of 150 mg/kg pentobarbital sodium for tissue collection, aligning with the committee’s guidelines for ethical animal research. The committee ensures that all research involving animals adheres to the principles of the 3Rs (replacement, reduction, refinement) to minimize pain or discomfort. All efforts were made to ensure the welfare of the animals throughout the study, and the methods used for euthanasia were in strict accordance with the guidelines for humane endpoints.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The datasets used and analyzed during the current study are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chuan Han, MD, Associate Chief Physician, Department of Endocrinology, General Hospital of the Western Theater Command, No. 270 Tianhui Road, Chengdu 610038, Sichuan Province, China. hanchuan3012005173@126.com
Received: October 8, 2024
Revised: December 16, 2024
Accepted: February 7, 2025
Published online: February 26, 2025
Processing time: 138 Days and 16.7 Hours
Revised: December 16, 2024
Accepted: February 7, 2025
Published online: February 26, 2025
Processing time: 138 Days and 16.7 Hours
Core Tip
Core Tip: Studies indicate that the exosome hydrogel composite demonstrates exceptional efficacy in facilitating the healing of deep burn wounds and managing infection. It has anti-inflammatory effects, promotes wound healing, and facilitates the transition of M1 macrophages to M2 macrophages by blocking the nuclear factor κB pathway, thereby offering a novel strategy for the clinical utilization of mesenchymal stem cell-derived exosomes.