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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Feb 26, 2025; 17(2): 101030
Published online Feb 26, 2025. doi: 10.4252/wjsc.v17.i2.101030
Published online Feb 26, 2025. doi: 10.4252/wjsc.v17.i2.101030
Fetal mice dermal mesenchymal stem cells promote wound healing by inducing M2 type macrophage polarization
Zhen-Yu Xia, Yi Wang, Nian Shi, Mei-Qi Lu, Yun-Xiang Deng, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong Province, China
Yong-Jun Qi, Department of Plastic Surgery & Burns, The Second Hospital of Shandong University, Jinan 250033, Shandong Province, China
Xing-Lei Wang, Jie Zhao, Du-Yin Jiang, Emergency Medicine Center, The Second Hospital of Shandong University, Jinan 250033, Shandong Province, China
Co-corresponding authors: Jie Zhao and Du-Yin Jiang.
Author contributions: Xia ZY and Wang Y contributed to the conceptualization of this study; Xia ZY and Shi N took part in the data curation; Xia ZY and Lu MQ participated in the formal analysis of this manuscript; Xia ZY and Deng YX contributed to the methodology; Xia ZY and Qi YJ contributed to the resources; Xia ZY and Wang XL contributed to the software; Xia ZY wrote the original draft; Zhao J and Jiang DY contributed to the writing - review & editing. Zhao J and Jiang DY are co-corresponding of this manuscript. Jiang DY provided guidance on the methodological design; Zhao J and Jiang DY jointly guided the conceptualization of our study, and completed the final revisions and confirmation of the manuscript.
Supported by National Natural Science Foundation of China, No. 81873934; and Jinan Science and Technology Planning Project, No. 202225065.
Institutional animal care and use committee statement: Ethical approval for all animal experiments conducted in this study was granted by the Institutional Animal Care and Use Committee at the Second Hospital of Shandong University (Approval No. KYLL-2023LW013). All animal procedures were carried out in strict accordance with institutional guidelines.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The datasets used and/or analyzed during the present study are available from the corresponding author on reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Du-Yin Jiang, MD, Emergency Medicine Center, The Second Hospital of Shandong University, No. 247 Beiyuan Street, Jinan 250033, Shandong Province, China.
Received: September 2, 2024
Revised: December 9, 2024
Accepted: February 7, 2025
Published online: February 26, 2025
Processing time: 174 Days and 17.5 Hours
Revised: December 9, 2024
Accepted: February 7, 2025
Published online: February 26, 2025
Processing time: 174 Days and 17.5 Hours
Core Tip
Core Tip: This study investigates the role of fetal dermal mesenchymal stem cells in wound healing by modulating macrophage polarization towards a pro-healing M2 phenotype. Using flow cytometry, reverse transcriptase polymerase chain reaction, and histology, we demonstrate that fetal dermal mesenchymal stem cells promote a reparative immune environment, accelerating wound closure, enhancing collagen deposition, and supporting vascular regeneration in a mouse model.