Retrospective Study
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World J Stem Cells. Feb 26, 2025; 17(2): 100621
Published online Feb 26, 2025. doi: 10.4252/wjsc.v17.i2.100621
Effect of tandem autologous stem cell transplantation on survival in pediatric patients with high-risk solid tumors in South China
Zi-Yan Luo, Li-Qun Fan, Wen-Ling Guo, Jian-Ping Yang, Zhuo-Yan Li, Yong-Xian Huang, Hua Jiang, Xiao-Hong Zhang
Zi-Yan Luo, Li-Qun Fan, Wen-Ling Guo, Jian-Ping Yang, Zhuo-Yan Li, Yong-Xian Huang, Hua Jiang, Division of Hematology and Oncology, Department of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510000, Guangdong Province, China
Xiao-Hong Zhang, Department of Pediatric Hematology Oncology, Guangdong Women and Children Hospital, Guangzhou 510000, Guangdong Province, China
Co-first authors: Zi-Yan Luo and Li-Qun Fan.
Co-corresponding authors: Hua Jiang and Xiao-Hong Zhang.
Author contributions: Luo ZY and Fan LQ are co-first authors who contributed equally to this work. Luo ZY and Fan LQ both contributed to drafting the initial manuscript; Luo ZY, Fan LQ, Jiang H, and Zhang XH designed and performed the research study; Guo WL, Yang JP, Li ZY, and Huang YX provided help and advice on experiments and analyzed the data. All authors contributed to editorial changes in the manuscript and have read and approved the final manuscript. All authors have contributed significantly to the work and agreed to be accountable for all aspects of the work. Jiang H and Zhang XH as co-corresponding authors, contributed equally to the conceptualization, supervision, and final manuscript revisions, justifying their shared authorship. Jiang H was designed as the primary contact for all journal correspondence.
Supported by Guangzhou Municipal Science and Technology Bureau, Municipal School and College Joint Funding Project, No. 2024A03J1240.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of Guangzhou Women and Children’s Medical Center, Guangzhou Medical University (Approval No. 2022-12008).
Informed consent statement: Informed consent was obtained from the legal guardians in this study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Data supporting the findings of this study are available from the corresponding author upon request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Hong Zhang, MD, Department of Pediatric Hematology Oncology, Guangdong Women and Children Hospital, No. 318 Renmin Road, Guangzhou 510000, Guangdong Province, China. 2018760286@gzhmu.edu.cn
Received: August 21, 2024
Revised: December 6, 2024
Accepted: February 12, 2025
Published online: February 26, 2025
Processing time: 186 Days and 20.3 Hours
Core Tip

Core Tip: This study evaluates the efficacy of tandem autologous stem cell transplantation (ASCT) in improving survival outcomes for pediatric patients with high-risk solid tumors, including neuroblastoma. The results demonstrate that tandem ASCT provides encouraging 5-year overall survival and event-free survival rates, with manageable toxicity and no transplant-related mortality. Key prognostic factors, such as age and lactate dehydrogenase levels at diagnosis, were identified. This study highlights the potential of tandem ASCT as a feasible therapeutic option for high-risk pediatric solid tumors, paving the way for further optimizing treatment strategies.