Melatonin regulation and the function of the periodontal ligament: Future perspective and challenges

doi:10.4252/wjsc.v17.i1.101347

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Jan 26, 2025 (publication date) through Jan 20, 2025

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Letter to the Editor

World J Stem Cells. Jan 26, 2025; 17(1): 101347
Published online Jan 26, 2025. doi: 10.4252/wjsc.v17.i1.101347

Melatonin regulation and the function of the periodontal ligament: Future perspective and challenges

Andrea Scribante

Andrea Scribante, Section of Dentistry, Department of Clinical, Surgical, Diagnostic and Paediatric Sciences, University of Pavia, Pavia 27100, Italy

Author contributions: Scribante A provided the conceptualization, methodology, software, investigation, writing-original draft preparation, writing-review and editing, and data visualization of this manuscript.

Conflict-of-interest statement: The author reports no relevant conflicts of interest for this article.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Andrea Scribante, PhD, Professor, Section of Dentistry, Department of Clinical, Surgical, Diagnostic and Paediatric Sciences, University of Pavia, Piazzale Golgi 2, Pavia 27100, Italy. andrea.scribante@unipv.it

Received: September 11, 2024
Revised: September 30, 2024
Accepted: November 26, 2024
Published online: January 26, 2025
Processing time: 130 Days and 14.3 Hours

Core Tip

Core Tip: The text highlights recent developments in periodontal research, showing that melatonin delays the aging of periodontal ligament stem cells and enhances their regenerative capacity, by acting on the Hippo-Yes-associated protein signaling pathway. This could be a breakthrough in the treatment of age-related periodontal disease.