Basic Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. May 26, 2024; 16(5): 560-574
Published online May 26, 2024. doi: 10.4252/wjsc.v16.i5.560
Effects of interleukin-10 treated macrophages on bone marrow mesenchymal stem cells via signal transducer and activator of transcription 3 pathway
Meng-Hao Lyu, Ce Bian, Yi-Ping Dou, Kang Gao, Jun-Ji Xu, Pan Ma
Meng-Hao Lyu, Jun-Ji Xu, Department of Periodontics, School of Stomatology, Capital Medical University, Beijing 100050, China
Ce Bian, Department of Orthodontics, School of Stomatology, Capital Medical University, Beijing 100050, China
Yi-Ping Dou, Kang Gao, Pan Ma, Department of Dental Implantology, School of Stomatology, Capital Medical University, Beijing 100050, China
Jun-Ji Xu, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, School of Stomatology, Capital Medical University, Beijing 100050, China
Jun-Ji Xu, Beijing Laboratory of Oral Health, Capital Medical University, Beijing 100050, China
Co-first authors: Meng-Hao Lyu and Ce Bian.
Co-corresponding authors: Jun-Ji Xu and Pan Ma.
Author contributions: Lyu MH, Bian C, Xu JJ, and Ma P designed the research; Lyu MH and Bian C performed the research; acquired and analyzed data form experiments and wrote the original draft; Dou YP and Gao K contributed new reagents/analytic tools; Lyu MH and Bian C revised the manuscript and edited the final version of the manuscript; Xu JJ and Ma P provided financial support and ensured the final manuscript, and they are the co-corresponding authors of this manuscript; Lyu MH and Bian C contributed equally to the work; and all authors have read and approved the final version of the manuscript.
Supported by National Natural Science Foundation of China, No. 81974153 and No. 82122015; and Beijing Natural Science Foundation, No. L222088.
Institutional animal care and use committee statement: The study was approved by the Animal Ethical and Welfare Committee of Beijing Stomatological Hospital Affiliated to Capital Medical University. The approval number is KQYY-2022.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at mapanxw@163.com.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Pan Ma, PhD, Professor, Department of Dental Implantology, School of Stomatology, Capital Medical University, No. 4 Tiantan Xili, Beijing 100050, China. mapanxw@163.com
Received: December 29, 2023
Revised: February 26, 2024
Accepted: April 12, 2024
Published online: May 26, 2024
Processing time: 146 Days and 22.9 Hours
Core Tip

Core Tip: This study investigated the mechanism of interleukin-10 (IL-10) affecting macrophages in inflammatory environments, observed the effects of different macrophages on the biological behavior and osteogenic differentiation of bone marrow mesenchymal stem cells, and found that IL-10/signal transducer and activator of transcription 3 signaling plays a crucial role in promoting bone formation by affecting macrophages. This study provides a new strategy for solving the problem of poor osteogenesis in bone defect repair caused by an excessive inflammatory response in clinical work.