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World J Stem Cells. Mar 26, 2024; 16(3): 245-256
Published online Mar 26, 2024. doi: 10.4252/wjsc.v16.i3.245
How mesenchymal stem cells transform into adipocytes: Overview of the current understanding of adipogenic differentiation
Shan-Shan Liu, Xiang Fang, Xin Wen, Ji-Shan Liu, Miribangvl Alip, Tian Sun, Yuan-Yuan Wang, Hong-Wei Chen
Shan-Shan Liu, Xin Wen, Miribangvl Alip, Tian Sun, Hong-Wei Chen, Department of Reumatology and Immunology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, Jiangsu Province, China
Xiang Fang, Department of Emergency, Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, Jiangsu Province, China
Ji-Shan Liu, Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China
Yuan-Yuan Wang, Anhui Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu 233000, Anhui Province, China
Co-first authors: Shan-Shan Liu and Xiang Fang.
Author contributions: Liu SS and Fang X contributed equally to write the paper; Wen X, Liu JS, Alip M, Sun T, and Wang YY provided data; Chen HW designed the review and were responsible for the final proofreading; and all authors have read and approve the final manuscript.
Supported by the National Natural Science Foundation of China, No. 82271843 and 31700779; the Key Project supported by Medical Science and Technology Development Foundation, Nanjing Department of Health, No. ZKX20019; and the Natural Science Foundation of Jiangsu Province, No. BK20200137.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong-Wei Chen, PhD, Associate Professor, Department of Reumatology and Immunology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Medical School, Nanjing University, No. 321 Zhongshan Road, Nanjing 210008, Jiangsu Province, China. chenhw@nju.edu.cn
Received: October 31, 2023
Peer-review started: October 31, 2023
First decision: December 19, 2023
Revised: January 15, 2024
Accepted: February 18, 2024
Article in press: February 18, 2024
Published online: March 26, 2024
Processing time: 145 Days and 18.7 Hours
Core Tip

Core Tip: Mesenchymal stem cells (MSCs) are able to differentiate into adipocytes, while the mechanism underlying the adipogenic differentiation of MSCs is not fully understood. Here, we summarize the function of signaling pathways, noncoding RNAs and epigenetic modification in MSC differentiation, and finally discuss the relationship between maladipogenic differentiation and diseases briefly.