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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Mar 26, 2024; 16(3): 232-236
Published online Mar 26, 2024. doi: 10.4252/wjsc.v16.i3.232
Published online Mar 26, 2024. doi: 10.4252/wjsc.v16.i3.232
Understanding host-graft crosstalk for predicting the outcome of stem cell transplantation
Luminita Labusca, Magnetic Materials and Sensors, National Institute of Research and Development for Technical Physics, Iasi 700050, Romania
Luminita Labusca, Orthopedics and Trauma, Emergency County Hospital Saint Spiridon, Iasi 700000, Romania
Florin Zugun-Eloae, Transcend, Regional Oncology Institute, Iasi 7000000, Romania
Author contributions: Labusca L and Zugun-Eloae F contributed to this paper, and the writing and editing of the manuscript; Labusca L designed the overall concept and outline of the manuscript; Zugun-Eloae F contributed to the discussion and design of the manuscript.
Supported by the Romanian Ministry of Research , Innovation and Digitization, CNCS/CCCDI-UEFISCDI, project number ERANET-EURONANOMED-3-OASIs, within PNCDI III (contract number 273/2022).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Luminita Labusca, MD, PhD, Senior Scientist, Magnetic Materials and Sensors, National Institute of Research and Development for Technical Physics, Boulevard Dimitrie Mangeron 47, Iasi 700050, Romania. drlluminita@yahoo.com
Received: December 22, 2023
Peer-review started: December 22, 2023
First decision: January 11, 2024
Revised: January 14, 2024
Accepted: February 18, 2024
Article in press: February 18, 2024
Published online: March 26, 2024
Peer-review started: December 22, 2023
First decision: January 11, 2024
Revised: January 14, 2024
Accepted: February 18, 2024
Article in press: February 18, 2024
Published online: March 26, 2024
Core Tip
Core Tip: Deterministic methods for modeling stem cell–host interactions are needed to ensure the safety and efficacy of stem cell-based therapies. This requires an in-depth understanding of the mechanism of action of the transplanted cells for each and every host condition(s) and asks for the establishment of adequate methods to predict, follow-up and determine the safety profile of the respective therapies.