O-linked β-N-acetylglucosaminylation may be a key regulatory factor in promoting osteogenic differentiation of bone marrow mesenchymal stromal cells

doi:10.4252/wjsc.v16.i3.228

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Mar 26, 2024 (publication date) through Jul 8, 2024

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Mar 26, 2024; 16(3): 228-231
Published online Mar 26, 2024. doi: 10.4252/wjsc.v16.i3.228

O-linked β-N-acetylglucosaminylation may be a key regulatory factor in promoting osteogenic differentiation of bone marrow mesenchymal stromal cells

Xu-Chang Zhou, Guo-Xin Ni

Xu-Chang Zhou, School of Sport Medicine and Rehabilitation, Beijing Sport University, Beijing 100084, China

Guo-Xin Ni, Department of Rehabilitation Medicine, The First Affiliated Hospital of Xiamen University, Xiamen 361003, Fujian Province, China

Author contributions: Zhou XC and Ni GX designed and coordinated the study; Zhou XC wrote the manuscript; and all authors approved the final version of the article.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Guo-Xin Ni, Doctor, MD, PhD, Chief Doctor, Chief Physician, Professor, Department of Rehabilitation Medicine, The First Affiliated Hospital of Xiamen University, No. 55 Zhenhai Road, Siming District, Xiamen 361003, Fujian Province, China. nigx@xmu.edu.cn

Received: December 7, 2023
Peer-review started: December 7, 2023
First decision: January 29, 2024
Revised: February 2, 2024
Accepted: February 29, 2024
Article in press: February 29, 2024
Published online: March 26, 2024
Processing time: 108 Days and 10.8 Hours

Core Tip

Core Tip: O-linked β-N-acetylglucosaminylation (O-GlcNAcylation), an important post-translational modification of proteins, widely involved in the regulation of biological processes such as signal transduction and proteasomal degradation, plays an essential role in the initiation and progression of various diseases such as bone metabolism. In this study, we emphasized that maintaining appropriate levels of O-GlcNAcylation is beneficial for the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). Insufficient or excessive levels of O-GlcNAcylation are detrimental to BMSC osteogenic differentiation.