Basic Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Feb 26, 2024; 16(2): 191-206
Published online Feb 26, 2024. doi: 10.4252/wjsc.v16.i2.191
Extracellular vesicles derived from mesenchymal stem cells mediate extracellular matrix remodeling in osteoarthritis through the transport of microRNA-29a
Fan Yang, Wan-Qi Xiong, Chen-Zhi Li, Ming-Jian Wu, Xiu-Zhi Zhang, Chun-Xiao Ran, Zhen-Hao Li, Yan Cui, Bao-Yi Liu, De-Wei Zhao
Fan Yang, Wan-Qi Xiong, Chen-Zhi Li, Ming-Jian Wu, Xiu-Zhi Zhang, Chun-Xiao Ran, Zhen-Hao Li, Yan Cui, Bao-Yi Liu, De-Wei Zhao, Department of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, Liaoning Province, China
Author contributions: Liu BY and Zhao DW was the guarantor and designed the study; Yang F and Xiong WQ participated in the acquisition, analysis, and interpretation of the data, and drafted the initial manuscript; Li CZ, Wu MJ, Zhang XZ, Ran CX, Li ZH, and Cui Y revised the article critically for important intellectual content.
Supported by Project of the National Natural Science Foundation of China, No. 82172398; Key Research Project of the Department of Education of Liaoning Province, No. LJKZZ20220148; Dalian Medical Science Research Project, No. 2111038; and Dalian Dengfeng Plan Medical Key Specialty Construction Project (2021), No. 243.
Institutional animal care and use committee statement: All animal studies were approved by the Animal Welfare and Ethics Committee of the Affiliated Zhongshan Hospital of Dalian University (No. 2022011010).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bao-Yi Liu, PhD, Chief, Professor, Surgeon, Teacher, Department of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, No. 6 Jiefang Street, Zhongshan District, Dalian 116001, Liaoning Province, China. liubaoyi-513@163.com
Received: October 26, 2023
Peer-review started: October 26, 2023
First decision: November 9, 2023
Revised: November 18, 2023
Accepted: January 30, 2024
Article in press: January 30, 2024
Published online: February 26, 2024
Processing time: 123 Days and 1.2 Hours
Core Tip

Core Tip: Knee osteoarthritis (KOA) is a common orthopedic condition with an uncertain etiology, involving genetics and biomechanics. Factors like changes in chondrocyte microenvironment, oxidative stress, inflammation, and immune responses affect KOA. Mesenchymal stem cells (MSCs) show promise in treatment. Recent research highlights microRNAs (miRNAs) within MSC-released extracellular vesicles that can potentially promote cartilage regeneration and hinder KOA. Engineered exosomes (Exos) loaded with miR-29a were used in a rat study for early-stage KOA treatment, showing superior pain reduction and joint improvement compared to standard Exos. These findings suggest that miR-29a-loaded Exos could be a novel therapeutic approach for early-stage KOA management.