Extracellular vesicles derived from mesenchymal stem cells mediate extracellular matrix remodeling in osteoarthritis through the transport of microRNA-29a
Fan Yang, Wan-Qi Xiong, Chen-Zhi Li, Ming-Jian Wu, Xiu-Zhi Zhang, Chun-Xiao Ran, Zhen-Hao Li, Yan Cui, Bao-Yi Liu, De-Wei Zhao
Fan Yang, Wan-Qi Xiong, Chen-Zhi Li, Ming-Jian Wu, Xiu-Zhi Zhang, Chun-Xiao Ran, Zhen-Hao Li, Yan Cui, Bao-Yi Liu, De-Wei Zhao, Department of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, Liaoning Province, China
Author contributions: Liu BY and Zhao DW was the guarantor and designed the study; Yang F and Xiong WQ participated in the acquisition, analysis, and interpretation of the data, and drafted the initial manuscript; Li CZ, Wu MJ, Zhang XZ, Ran CX, Li ZH, and Cui Y revised the article critically for important intellectual content.
Supported by Project of the National Natural Science Foundation of China, No. 82172398; Key Research Project of the Department of Education of Liaoning Province, No. LJKZZ20220148; Dalian Medical Science Research Project, No. 2111038; and Dalian Dengfeng Plan Medical Key Specialty Construction Project (2021), No. 243.
Institutional animal care and use committee statement: All animal studies were approved by the Animal Welfare and Ethics Committee of the Affiliated Zhongshan Hospital of Dalian University (No. 2022011010).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Bao-Yi Liu, PhD, Chief, Professor, Surgeon, Teacher, Department of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, No. 6 Jiefang Street, Zhongshan District, Dalian 116001, Liaoning Province, China. liubaoyi-513@163.com
Received: October 26, 2023
Peer-review started: October 26, 2023
First decision: November 9, 2023
Revised: November 18, 2023
Accepted: January 30, 2024
Article in press: January 30, 2024
Published online: February 26, 2024
Processing time: 123 Days and 1.2 Hours
