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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Feb 26, 2024; 16(2): 176-190
Published online Feb 26, 2024. doi: 10.4252/wjsc.v16.i2.176
Published online Feb 26, 2024. doi: 10.4252/wjsc.v16.i2.176
High quality repair of osteochondral defects in rats using the extracellular matrix of antler stem cells
Yu-Su Wang, Wen-Ying Wang, Chun-Yi Li, Institute of Antler Science and Product Technology, Changchun Sci-Tech University, Changchun 130000, Jilin Province, China
Yu-Su Wang, Zhong-Mei He, Quan-Min Zhao, College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, Jilin Province, China
Wen-Hui Chu, School of Life Science, Taizhou University, Taizhou 318000, Zhejiang Province, China
Jing-Jie Zhai, Department of Oral Implantology, Hospital of Stomatology, Jilin University, Changchun 130000, Jilin Province, China
Co-first authors: Yu-Su Wang and Wen-Hui Chu.
Author contributions: Wang YS, Zhao QM, and Li CY contributed to the conceptualization; Wang YS, Zhai JJ, Wang WY, and He ZM participated in the in vitro methodology; Wang YS, Chu WH, Wang WY, and Zhao QM were involved in the in vivo methodology; Wang YS, Zhai JJ, and He ZM took part in data analysis; Wang YS and Chu WH wrote the manuscript; Chu WH, He ZM, and Zhao QM contributed to the review and editing of this article; and all authors have read and agreed to the published version of the manuscript.
Supported by National Natural Science Foundation of China , No. U20A20403 .
Institutional animal care and use committee statement: This study was conducted in accordance with the Animal Ethics Committee of the Institute of Antler Science and Product Technology, Changchun Sci-Tech University (AEC No: CKARI202309).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chun-Yi Li, PhD, Professor, Institute of Antler Science and Product Technology, Changchun Sci-Tech University, No. 1345 Pudong Road, Changchun 130000, Jilin Province, China. lichunyi1959@163.com
Received: October 20, 2023
Peer-review started: October 20, 2023
First decision: December 5, 2023
Revised: December 15, 2023
Accepted: January 19, 2024
Article in press: January 19, 2024
Published online: February 26, 2024
Processing time: 128 Days and 14.7 Hours
Peer-review started: October 20, 2023
First decision: December 5, 2023
Revised: December 15, 2023
Accepted: January 19, 2024
Article in press: January 19, 2024
Published online: February 26, 2024
Processing time: 128 Days and 14.7 Hours
Core Tip
Core Tip: Our study has shown that a decellularized xenogeneic extracellular matrix (ECM) derived from antler reserve mesenchymal cells, provided high quality repair of osteochondral defects in rat knee joints. This was achieved without detectable immune reaction in the recipient animals. This finding provides insights for the development of an effective therapeutic material for osteochondral defect repair and highlights the opportunity for use of this novel stem cell-derived ECM.