Letter to the Editor
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Dec 26, 2024; 16(12): 1106-1109
Published online Dec 26, 2024. doi: 10.4252/wjsc.v16.i12.1106
Innovative hydrogel delivery of bone marrow stromal cell-derived exosomes for enhanced bone healing
Yue Ding, Fang Lin, Xiao-Ting Liang
Yue Ding, Xiao-Ting Liang, Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200120, China
Yue Ding, Department of Organ Transplantation, Naval Medical University, Shanghai 200000, China
Fang Lin, Shanghai Heart Failure Research Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China
Co-first authors: Yue Ding and Fang Lin.
Author contributions: Ding Y and Lin F contributed equally to this work and as co-first authors of this manuscript. Ding Y, Lin F, and Liang XT wrote the original draft; Liang XT contributed to reviewing and editing the manuscript. All the authors have read and approved the manuscript.
Supported by the National Natural Science Foundation of China, No. 81500207; and the Pyramid Talent Project, China, No. YQ677.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Ting Liang, MD, PhD, Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, No. 150 Jimo Road, Shanghai 200120, China. liangxt@tongji.edu.cn
Received: June 11, 2024
Revised: October 2, 2024
Accepted: November 29, 2024
Published online: December 26, 2024
Processing time: 184 Days and 23.1 Hours
Core Tip

Core Tip: This study introduces a novel hydrogel system embedded with bone marrow stromal cell-derived exosomes that enhances bone regeneration by modulating inflammation and promoting angiogenesis. The dual-role capability of bone marrow stromal cell-derived exosomes in directing cell fate is a significant innovation, demonstrating enhanced angiogenesis and osteogenic differentiation. When validated in a murine fracture model, this approach showed promising potential for clinical application in the treatment of large bone defects. Further detailed investigations are needed to fully understand the therapeutic potential of this innovative strategy.