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World J Stem Cells. Oct 26, 2024; 16(10): 860-872
Published online Oct 26, 2024. doi: 10.4252/wjsc.v16.i10.860
Bioengineering breakthroughs: The impact of stem cell models on advanced therapy medicinal product development
José Mauro Granjeiro, Priscila Grion de Miranda Borchio, Icaro Paschoal Brito Ribeiro, Katiucia Batista Silva Paiva
José Mauro Granjeiro, Division of Biological Metrology, The National Institute of Metrology, Quality, and Technology, Duque de Caxias 25250020, Rio de Janeiro, Brazil
Priscila Grion de Miranda Borchio, Laboratory of Regenerative Medicine, Arthur Sá Earp Neto University, Petropolis 25680120, Rio de Janeiro, Brazil
Icaro Paschoal Brito Ribeiro, Katiucia Batista Silva Paiva, Laboratory of Extracellular Matrix Biology and Cellular Interaction, Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508000, São Paulo, Brazil
Co-corresponding authors: José Mauro Granjeiro and Katiucia Batista Silva Paiva.
Author contributions: Granjeiro JM and Paiva KBS contributed to this paper equally in design of the overall concept and outline of the manuscript, in writing and editing of the manuscript and generation of its illustrations, in reviewing the literature, and in securing of funding support, they are the co-corresponding authors of this manuscript; Borchio PGM and Ribeiro IPB made important intellectual contributions to the writing and editing of the manuscript and to the review of the literature. All authors read and approved the final draft of the manuscript.
Supported by São Paulo Research Foundation/FAPESP, No. 2020/11564-6 and No. 2019/27001-3; the National Council for Scientific and Technological Development/CNPq, No. 400030/2018-7; and Network NanoHealth/FAPERJ, No. E-26/10.000981/2019 and No. E-26/010.000210/2019/FAPERJ.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: José Mauro Granjeiro, PhD, Senior Researcher, Division of Biological Metrology, The National Institute of Metrology, Quality, and Technology, Avenida Nossa Sra. das Graças, 50 - Xerém, Duque de Caxias 25250020, Rio de Janeiro, Brazil. jmgranjeiro@inmetro.gov.br
Received: April 30, 2024
Revised: July 22, 2024
Accepted: September 23, 2024
Published online: October 26, 2024
Processing time: 177 Days and 9.2 Hours
Core Tip

Core Tip: Stem cells play a crucial role in tissue engineering by offering the potential for regenerating of damaged tissues, which is critical for developing advanced therapy medicinal products. Stem cells can differentiate into specific cell types and promote tissue repair through various mechanisms. When combined with tissue engineering techniques, stem cell therapy enhances cell viability, differentiation, and therapeutic efficacy, overcoming disease treatment limitations. However, translating stem cell research into approved clinical therapies has been challenging. Regulatory bodies have provided guidelines to ensure the safety and efficacy of advanced therapy medicinal products utilizing stem cells before the approval for clinical use.