Copyright
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Jan 26, 2024; 16(1): 7-18
Published online Jan 26, 2024. doi: 10.4252/wjsc.v16.i1.7
Published online Jan 26, 2024. doi: 10.4252/wjsc.v16.i1.7
Use of priming strategies to advance the clinical application of mesenchymal stromal/stem cell-based therapy
Vitale Miceli, Department of Research, Istituto Mediterraneo per i Trapianti e Terapie ad alta Specializzazione, Palermo 90127, Italy
Author contributions: Miceli V designed the general concept and outline of the manuscript, reviewed the literature, wrote and edited the manuscript and illustration.
Conflict-of-interest statement: The author reported no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Vitale Miceli, PhD, Academic Editor, Research Scientist, Department of Research, Istituto Mediterraneo per i Trapianti e Terapie ad alta Specializzazione, Via Tricomi 5, Palermo 90127, Italy. vmiceli@ismett.edu
Received: November 15, 2023
Peer-review started: November 15, 2023
First decision: December 17, 2023
Revised: December 18, 2023
Accepted: December 28, 2023
Article in press: December 28, 2023
Published online: January 26, 2024
Peer-review started: November 15, 2023
First decision: December 17, 2023
Revised: December 18, 2023
Accepted: December 28, 2023
Article in press: December 28, 2023
Published online: January 26, 2024
Core Tip
Core Tip: Mesenchymal stromal/stem cells (MSCs) offer important therapeutic effects in the field of regenerative medicine. Their key role lies in the production of paracrine factors that modulate tissue environments and allow their repair following insults. Recently, MSC-derived products such as exosomes and conditioned media are replacing whole MSCs in clinical applications. In this regard, to optimize the results of MSC-based treatment, researchers have explored priming strategies in order to enhance MSC properties. Realizing the full potential of MSC therapy depends on identifying the right tissue source and developing priming strategies specific to the disease being treated.