Systematic Reviews
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Jun 26, 2023; 15(6): 632-653
Published online Jun 26, 2023. doi: 10.4252/wjsc.v15.i6.632
Current overview of induced pluripotent stem cell-based blood-brain barrier-on-a-chip
Arielly da Hora Alves, Mariana Penteado Nucci, Nicole Mastandrea Ennes do Valle, Juliana Morais Missina, Javier Bustamante Mamani, Gabriel Nery Albuquerque Rego, Olivia Furiama Metropolo Dias, Murilo Montenegro Garrigós, Fernando Anselmo de Oliveira, Lionel Fernel Gamarra
Arielly da Hora Alves, Mariana Penteado Nucci, Nicole Mastandrea Ennes do Valle, Juliana Morais Missina, Javier Bustamante Mamani, Gabriel Nery Albuquerque Rego, Olivia Furiama Metropolo Dias, Murilo Montenegro Garrigós, Fernando Anselmo de Oliveira, Lionel Fernel Gamarra, Hospital Israelita Albert Einstein, São Paulo 05529-060, São Paulo, Brazil
Mariana Penteado Nucci, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-010, São Paulo, Brazil
Author contributions: Alves ADH, Nucci MP, Ennes do Valle NM, Missina JM, and Gamarra LF conceived and designed this study; Alves ADH, Nucci MP, Ennes do Valle NM, Rego GNA, and Gamarra LF performed the literature review; Alves ADH, Nucci MP, Ennes do Valle NM, Rego GNA, Mamani JB, and Missina JM performed the data extraction and critical review; Alves ADH, Nucci MP, Ennes do Valle NM, Missina JM, de Oliveira FA, and Mamani JB interpreted and analyzed the collected data; Alves ADH, Nucci MP, Ennes do Valle NM, Missina JM, Dias OFM, Garrigós MM, and Gamarra LF wrote this review; All authors reviewed and approved the final manuscript as submitted.
Supported by CNPq, Nos. 308901/2020-7 and 400856/2016-6; FAPESP, Nos. 2019/21070-3, 2017/17868-4, and 2016/21470-3; SisNANO 2.0/MCTIC, No. 442539/2019-3; and the National Institute of Science and Technology Complex Fluids, INCT-FCx.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
PRISMA 2009 Checklist statement: The authors have read the PRISMA guidelines, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lionel Fernel Gamarra, PhD, Academic Research, Professor, Research Associate, Teacher, Hospital Israelita Albert Einstein, Av. Albert Einstein, 627/701, Morumbi, São Paulo 05529-060, São Paulo, Brazil. lgamarra@einstein.br
Received: February 15, 2023
Peer-review started: February 15, 2023
First decision: April 10, 2023
Revised: April 10, 2023
Accepted: May 8, 2023
Article in press: May 8, 2023
Published online: June 26, 2023
Processing time: 130 Days and 16.5 Hours
Core Tip

Core Tip: This systematic review provided a current perspective on the applicability of induced pluripotent stem cells within blood-brain barrier (BBB)-on-a-chip with high technology advances in commercial chips and promotion of an efficient human neurovascular unit, able to screen for drugs, mimic brain dysfunctions, such as stroke and Huntington’s disease, and suitable for future personalized therapeutic approaches. However, the composition and construction of the BBB models lack consensus in the literature.