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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Jun 26, 2023; 15(6): 576-588
Published online Jun 26, 2023. doi: 10.4252/wjsc.v15.i6.576
Published online Jun 26, 2023. doi: 10.4252/wjsc.v15.i6.576
Clinical relevance of stem cells in lung cancer
Horacio Eduardo Romeo, María Laura Barreiro Arcos, School of Engineering and Agrarian Sciences, Pontifical Catholic University of Argentina, Institute of Biomedical Research (BIOMED-UCA-CONICET), CABA C1107AAZ, Buenos Aires, Argentina
Author contributions: Romeo HE and Barreiro Arcos ML compiled the updated information, wrote the manuscript and prepared the figures.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: María Laura Barreiro Arcos, PhD, Research Scientist, School of Engineering and Agrarian Sciences, Pontifical Catholic University of Argentina, Institute of Biomedical Research (BIOMED-UCA-CONICET), Av. Alicia Moreau de Justo 1600, CABA C1107AZZ, Buenos Aires, Argentina. mlbarreiro@yahoo.com.ar
Received: January 31, 2023
Peer-review started: January 31, 2023
First decision: February 10, 2023
Revised: March 18, 2023
Accepted: May 8, 2023
Article in press: May 8, 2023
Published online: June 26, 2023
Processing time: 145 Days and 18.5 Hours
Peer-review started: January 31, 2023
First decision: February 10, 2023
Revised: March 18, 2023
Accepted: May 8, 2023
Article in press: May 8, 2023
Published online: June 26, 2023
Processing time: 145 Days and 18.5 Hours
Core Tip
Core Tip: Lung cancer stem cells (CSCs) could have a functional role in primary tumor initiation, invasion and metastasis, resistance to chemotherapeutic drugs, and recurrence in lung cancer. To improve lung cancer treatments, it is necessary to identify and characterize CSCs populations in lung tissue and develop targeted therapies against these cell types. This review discusses the current knowledge on CSCs in lung tissue and future perspectives in lung cancer treatment.