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Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Jun 26, 2023; 15(6): 502-513
Published online Jun 26, 2023. doi: 10.4252/wjsc.v15.i6.502
Adipokines regulate mesenchymal stem cell osteogenic differentiation
Zhong-Hua Xu, Chen-Wei Xiong, Kai-Song Miao, Zhen-Tang Yu, Jun-Jie Zhang, Chang-Lin Yu, Yong Huang, Xin-Die Zhou
Zhong-Hua Xu, Department of Orthopedics, Jintan Hospital Affiliated to Jiangsu University, Changzhou 213200, Jiangsu Province, China
Chen-Wei Xiong, Kai-Song Miao, Zhen-Tang Yu, Jun-Jie Zhang, Chang-Lin Yu, Yong Huang, Xin-Die Zhou, Department of Orthopedics, The Affiliated Changzhou Second People’s Hospital of Nanjing Medical University, Changzhou 213000, Jiangsu Province, China
Chen-Wei Xiong, Kai-Song Miao, Zhen-Tang Yu, Jun-Jie Zhang, Chang-Lin Yu, Yong Huang, Xin-Die Zhou, Changzhou Medical Center, Nanjing Medical University, Changzhou 213000, Jiangsu Province, China
Xin-Die Zhou, Department of Orthopedics, Gonghe County Hospital of Traditional Chinese Medicine, Hainan Tibetan Autonomous Prefecture 811800, Qinghai Province, China
Author contributions: Xu ZH and Xiong CW contributed equally to this work; Xu ZH contributed to the conceptualization, methodology, and software; Xiong CW contributed to the data curation, and writing-original draft preparation; Miao KS and Yu ZT contributed to the visualization and investigation; Zhang JJ and Yu CL contributed to the supervision, software, and validation; Huang Y contributed to the writing-reviewing and editing; Zhou XD contributed to the data collection.
Supported by the Changzhou Science & Technology Program, No. CJ20210104, CJ20220120, and CJ20210005; Qinghai Province Health System Guidance Plan Project, No. 2022-wjzdx-106; Young Talent Development Plan of Changzhou Health commission, No. CZQM2020059; and Top Talent of Changzhou “The 14th Five-Year Plan” High-Level Health Talents Training Project, No. 2022CZBJ059 and 2022CZBJ061.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xin-Die Zhou, MD, Department of Orthopedics, The Affiliated Changzhou Second People’s Hospital of Nanjing Medical University, No. 29 Xinglong Lane, Tianning District, Changzhou 213000, Jiangsu Province, China. zhouxindie@njmu.edu.cn
Received: November 14, 2022
Peer-review started: November 14, 2022
First decision: February 21, 2023
Revised: February 26, 2023
Accepted: April 24, 2023
Article in press: April 24, 2023
Published online: June 26, 2023
Processing time: 224 Days and 12.1 Hours
Core Tip

Core Tip: Bone tissue supports and protects the organs of the human body. There is a close relationship between the immune system and bone homeostasis. Adipose tissue is an essential accessory tissue around bone tissue, which regulates bone homeostasis through the secretion of adipocytokines. There are many types of adipokines, but only some have been studied in detail. Different adipokines affect the behavior and differentiation of mesenchymal stem cells under different local microenvironments and surrounding inflammation, thus coordinating and participating in the regulation of bone homeostasis.