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World J Stem Cells. Mar 26, 2023; 15(3): 83-89
Published online Mar 26, 2023. doi: 10.4252/wjsc.v15.i3.83
Mesenchymal stem/stromal cells-derived exosomes for osteoporosis treatment
Kai-Lun Huo, Tie-Yi Yang, Wei-Wei Zhang, Jin Shao
Kai-Lun Huo, Postgraduate Training Base in Shanghai Gongli Hospital, Ningxia Medical University, Yinchuan 750004, the Ningxia Hui Autonomous Region, China
Tie-Yi Yang, Jin Shao, Department of Orthopedics, Pudong New Area Gongli Hospital, School of Medical Technology, University of Shanghai for Science and Technology, Shanghai 200135, China
Wei-Wei Zhang, Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
Author contributions: Shao J and Zhang WW were responsible for the concept design; Huo KL, Shao J and Zhang WW wrote the main manuscript text and prepared Figures 1 and 2; Yang TY provided technical support; all authors reviewed the manuscript.
Supported by National Natural Science Foundation of China, No. 81703533; Natural Science Foundation of Shanghai, No. 20ZR1449500; Shanghai Jiao Tong University Medical Engineering Cross Fund, No. YG2019GD02; Science Technology Development Fund of Shanghai Pudong New Area, No. PKJ2020-Y28; and Medical Discipline Construction Project of Pudong Health Committee of Shanghai, No. PWYts2021-05.
Conflict-of-interest statement: The authors declare no conflict of interests.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jin Shao, MD, PhD, Associate Professor, Deputy Director, Department of Orthopedics, Pudong New Area Gongli Hospital, School of Medical Technology, University of Shanghai for Science and Technology, No. 219 Miaopu Road, Pudong New Area, Shanghai 200135, China. shaojin_1977@126.com
Received: December 26, 2022
Peer-review started: December 26, 2022
First decision: January 3, 2023
Revised: January 17, 2023
Accepted: March 16, 2023
Article in press: March 16, 2023
Published online: March 26, 2023
Core Tip

Core Tip: Osteoporosis is one of the major diseases endangering bone health in the elderly. The existing treatment drugs have problems such as long-term administration and side effects; thus, it is fundamentally difficult to cure osteoporosis. Exosomes derived from mesenchymal stem cells (MSCs) are vesicles that deliver signals and molecules between cells and have shown substantial positive effects in pre-clinical trials. In this review, we summarize the latest progress of MSCs-derived exosomes in the regulation of bone metabolism.