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Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Mar 26, 2023; 15(3): 31-51
Published online Mar 26, 2023. doi: 10.4252/wjsc.v15.i3.31
Clinical trials using dental stem cells: 2022 update
Wen-Peng Song, Lu-Yuan Jin, Meng-Di Zhu, Hao Wang, Deng-Sheng Xia
Wen-Peng Song, Hao Wang, Department of Stomatology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
Lu-Yuan Jin, Meng-Di Zhu, Deng-Sheng Xia, Department of General Dentistry and Integrated Emergency Dental Care, Beijing Stomatological Hospital, Capital Medical University, Beijing 100050, China
Author contributions: Song WP and Zhu MD contributed to the data collection and manuscript writing; Song WP and Jin LY contributed to the data analysis; Xia DS, Wang H, and Jin LY contributed to the study design and supervision; all authors have read and approved the final manuscript.
Supported by the National Natural Science Foundation of China, No. 82071073 and No. 82270951.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Deng-Sheng Xia, DDS, Assistant Professor, Department of General Dentistry and Integrated Emergency Dental Care, Beijing Stomatological Hospital, Capital Medical University, No. 4 Tiantan Xili, Dongcheng District, Beijing 100050, China. dsxia@mail.ccmu.edu.cn
Received: December 5, 2022
Peer-review started: December 5, 2022
First decision: January 11, 2023
Revised: January 20, 2023
Accepted: March 8, 2023
Article in press: March 8, 2023
Published online: March 26, 2023
Core Tip

Core Tip: Since dental pulp stem cells were first isolated and identified in 2000, a variety of dental stem cells (DSCs) have been reported. DSCs have shown satisfactory clinical effects in the treatment of a variety of diseases and have great potential for clinical application. This paper will summarize DSC-based clinical trials and put forward the current limitations and perspectives to accelerate and extend the clinical application of DSCs.