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World J Stem Cells. May 26, 2022; 14(5): 318-329
Published online May 26, 2022. doi: 10.4252/wjsc.v14.i5.318
Mesenchymal stem cell-derived exosomes: A novel and potential remedy for cutaneous wound healing and regeneration
Jia-Chen Hu, Chen-Xi Zheng, Bing-Dong Sui, Wen-Jia Liu, Yan Jin
Jia-Chen Hu, Chen-Xi Zheng, Bing-Dong Sui, Yan Jin, State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, Xi’an 710032, Shaanxi Province, China
Wen-Jia Liu, National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, Precision Medicine Institute, Institute for Stem Cell and Regenerative Medicine, The Second Affiliated Hospital, Xi’an Jiaotong University, Xi’an 710032, Shaanxi Province, China
Author contributions: All authors actively reviewed and revised the manuscript and approved the finally submitted manuscript; Hu JC and Zheng CX contributed equally to this work.
Supported by National Natural Science Foundation of China, No. 32000974, No. 82170988, and No. 81930025.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan Jin, DDS, PhD, Professor, State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi International Joint Research Center for Oral Diseases, Center for Tissue Engineering, School of Stomatology, The Fourth Military Medical University, No. 145 West Changle Road, Xi’an 710032, Shaanxi Province, China. yanjin@fmmu.edu.cn
Received: December 31, 2021
Peer-review started: December 31, 2021
First decision: March 13, 2022
Revised: April 11, 2022
Accepted: May 21, 2022
Article in press: May 21, 2022
Published online: May 26, 2022
Processing time: 146 Days and 3.2 Hours
Core Tip

Core Tip: The promotion of wound healing is an important obstacle in the treatment of trauma in clinic. Exosomes derived from mesenchymal stem cells (MSCs) may provide a novel remedy with advantages and prospects. Herein, we discuss the role and the underlying mechanisms via which MSC-derived exosomes improve cutaneous wound healing, and elaborate the potentials and future perspectives of MSC-exosome application in clinical practice.