Systematic Reviews
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World J Stem Cells. Dec 26, 2022; 14(12): 851-867
Published online Dec 26, 2022. doi: 10.4252/wjsc.v14.i12.851
Biomaterial application strategies to enhance stem cell-based therapy for ischemic stroke
Asmaa’ Mohd Satar, Farah Amna Othman, Suat Cheng Tan
Asmaa’ Mohd Satar, Farah Amna Othman, Suat Cheng Tan, School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan 16150, Malaysia
Author contributions: Tan SC designed the research; Mohd Satar A and Othman FA performed the literature review and analysis; All authors contributed to writing of the paper and gave approval of the final version.
Supported by the Universiti Sains Malaysia Research University Individual Grant, No. 1001/PPSK/8012273.
Conflict-of-interest statement: All the authors declare having no conflicts of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Suat Cheng Tan, PhD, Lecturer, School of Health Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan 16150, Malaysia. tansc@usm.my
Received: September 11, 2022
Peer-review started: September 11, 2022
First decision: October 20, 2022
Revised: October 29, 2022
Accepted: December 6, 2022
Article in press: December 6, 2022
Published online: December 26, 2022
Processing time: 100 Days and 23.1 Hours
Core Tip

Core Tip: Ischemic stroke is becoming a significant health issue globally. An increasing number of studies have proposed the applications of regenerative stem cells for the treatment of this neurodegenerative disease. We critically reviewed the literature on biomaterial application to enhance the therapeutic potential of stem/progenitor cell therapy for ischemic stroke. Despite the limited evidence collected to translate this evidence into clinical practice, it is postulated that application of stem cells as regenerative treatment for stroke is practicable and beneficial for stroke patients, especially those in the chronic phase of stroke which could not be cured by any other established means.