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World J Stem Cells. Jan 26, 2022; 14(1): 92-103
Published online Jan 26, 2022. doi: 10.4252/wjsc.v14.i1.92
Epigenetic regulation by long noncoding RNAs in osteo-/adipogenic differentiation of mesenchymal stromal cells and degenerative bone diseases
Kai Xia, Li-Yuan Yu, Xin-Qi Huang, Zhi-He Zhao, Jun Liu
Kai Xia, Li-Yuan Yu, Xin-Qi Huang, Zhi-He Zhao, Jun Liu, State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China
Kai Xia, Li-Yuan Yu, Xin-Qi Huang, Zhi-He Zhao, Jun Liu, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Xia K and Yu LY contributed equally to this work; Liu J and Zhao ZH contributed to the conception of the review; Xia K and Yu LY conducted literature research and drafted the manuscript; Huang XQ revised the manuscript critically; all authors read and approved the final version of the manuscript.
Supported by the National Natural Science Foundation of China, No. 81870743 and No. 81771048.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jun Liu, DDS, PhD, Professor, State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, 3rd Section, South Renmin Road, Chengdu 610041, Sichuan Province, China. junliu@scu.edu.cn
Received: February 26, 2021
Peer-review started: February 26, 2021
First decision: June 16, 2021
Revised: July 7, 2021
Accepted: January 5, 2022
Article in press: January 5, 2022
Published online: January 26, 2022
Processing time: 327 Days and 18.9 Hours
Core Tip

Core Tip: In this review, we summarized the roles of long noncoding RNAs (lncRNAs) played in mesenchymal stromal cells (MSCs) differentiation and common degenerative bone diseases through reciprocal interactions between lncRNAs and epigenetic modifiers, focusing on the most common epigenetic mechanisms: DNA methylation and histone modifications. It is our hope that this review may provide an updated summary that sheds light on the lncRNA-based precise regulation of the MSC differentiation process and highlights possible therapeutic targets of degenerative bone diseases.