Letter to the Editor
Copyright ©©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Jan 26, 2022; 14(1): 142-145
Published online Jan 26, 2022. doi: 10.4252/wjsc.v14.i1.142
Insight into generation of induced mesenchymal stem cells from induced pluripotent cells
Mahmood S Choudhery, Ruhma Mahmood
Mahmood S Choudhery, Department of Biomedical Sciences, King Edward Medical University, Lahore 54000, Punjab, Pakistan
Mahmood S Choudhery, Department of Genetics and Molecular Biology, University of Health Sciences, Lahore 54600, Punjab, Pakistan
Ruhma Mahmood, Stem Cells Laboratory, Allama Iqbal Medical College, Lahore 54000, Punjab, Pakistan
Author contributions: Choudhery MS and Mahmood R searched the literature and designed and wrote the manuscript.
Conflict-of-interest statement: The authors do not have any financial conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mahmood S Choudhery, PhD, Tenured Associate Professor, Department of Genetics and Molecular Biology, University of Health Sciences, Khayaban-e-Jamia Punjab, Lahore 54600, Punjab, Pakistan. ms20031@yahoo.com
Received: September 9, 2021
Peer-review started: September 9, 2021
First decision: October 17, 2021
Revised: October 25, 2021
Accepted: December 23, 2021
Article in press: December 23, 2021
Published online: January 26, 2022
Core Tip

Core Tip: Regenerative potential of mesenchymal stem cells (MSCs) have been explored in a number of preclinical and clinical studies for the treatment of various diseases and disorders. However, factors such as low number of MSCs in donor tissues, heterogeneity, limited in vitro proliferative potential and early senescence in in vitro cultures restrict MSC use clinically. Novel methods to generate induced MSCs from induced pluripotent stem cells have been explored. Development and optimization of such protocols is necessary to evaluate the regenerative potential of induced MSCs in vivo and in vitro.