Review
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Sep 26, 2021; 13(9): 1248-1277
Published online Sep 26, 2021. doi: 10.4252/wjsc.v13.i9.1248
Current evidence on potential of adipose derived stem cells to enhance bone regeneration and future projection
Quang Le, Vedavathi Madhu, Joseph M Hart, Charles R Farber, Eli R Zunder, Abhijit S Dighe, Quanjun Cui
Quang Le, Joseph M Hart, Abhijit S Dighe, Quanjun Cui, Department of Orthopaedic Surgery, University of Virginia School of Medicine, Charlottesville, VA 22908, United States
Vedavathi Madhu, Orthopaedic Surgery Research, Thomas Jefferson University, Philadelphia, PA 19107, United States
Charles R Farber, Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, United States
Charles R Farber, Departments of Public Health Sciences and Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA 22908, United States
Eli R Zunder, Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, United States
Author contributions: Dighe AS and Cui Q contributed conception and designed the research; Le Q, Madhu V and Dighe AS contributed literature search, preparation of the first draft, tables and figures; Le Q, Hart JM and Cui Q contributed clinical trials database search and review; Dighe AS, Farber CR, Zunder ER and Cui Q contributed preparation of semifinal draft after reviewing the first draft; all authors wrote, read and approved the final manuscript.
Conflict-of-interest statement: The authors declare no conflict of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Quanjun Cui, MD, Attending Doctor, Professor, Surgeon, Department of Orthopaedic Surgery, University of Virginia School of Medicine, 400 Ray C. Hunt Drive, Suite 330, Charlottesville, VA 22903, United States. qc4q@virginia.edu
Received: March 28, 2021
Peer-review started: March 28, 2021
First decision: May 12, 2021
Revised: May 22, 2021
Accepted: August 18, 2021
Article in press: August 18, 2021
Published online: September 26, 2021
Processing time: 173 Days and 13.7 Hours
Core Tip

Core Tip: This review systematically examined current progress and future projections of Adipose-derived Stem Cells (ADSCs) use in bone regeneration. Introduction covered the regulatory aspects of stem cell therapy and scientific concerns regarding stem cell use including ADSCs. We then analyze clinical and pre-clinical studies using ADSCs for the treatment of bone defects. We also evaluate the current understanding of ADSC’s surface receptors and therapeutic subpopulations. Overall, we conclude that while mixed outcomes have been reported, a more rigorous definition of ADSCs, selection of osteogenic subpopulations, and understanding of signaling pathways will unleash ADSCs as a powerful tool in bone regeneration.