Review
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Sep 26, 2021; 13(9): 1231-1247
Published online Sep 26, 2021. doi: 10.4252/wjsc.v13.i9.1231
Stem cell therapies in cardiac diseases: Current status and future possibilities
Tais Hanae Kasai-Brunswick, Adriana Bastos Carvalho, Antonio Carlos Campos de Carvalho
Tais Hanae Kasai-Brunswick, Antonio Carlos Campos de Carvalho, National Center of Structural Biology and Bioimaging, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil
Tais Hanae Kasai-Brunswick, Adriana Bastos Carvalho, Antonio Carlos Campos de Carvalho, National Institute of Science and Technology in Regenerative Medicine, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil
Adriana Bastos Carvalho, Antonio Carlos Campos de Carvalho, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro 21941-902, RJ, Brazil
Author contributions: Kasai-Brunswick TH and Carvalho AB wrote the manuscript and prepared the figure; Campos de Carvalho AC wrote the manuscript and revised the final version.
Supported by Rio de Janeiro State Research Foundation, No. 252042, No. 250671 and No. 241703.
Conflict-of-interest statement: We declare no conflict of interest related to this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Antonio Carlos Campos de Carvalho, MD, PhD, Professor, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Av. Carlos Chagas Filho, No. 373, Room G2-053, Rio de Janeiro 21941-902, RJ, Brazil. acarlos@biof.ufrj.br
Received: March 1, 2021
Peer-review started: March 1, 2021
First decision: July 18, 2021
Revised: July 26, 2021
Accepted: August 10, 2021
Article in press: August 10, 2021
Published online: September 26, 2021
Processing time: 200 Days and 15.9 Hours
Core Tip

Core Tip: The challenge to regenerate an adult heart has stimulated the field of stem cell therapies to search for a therapeutic alternative to promote robust cardiac repair. In this review, we will discuss several types of cell therapy, which have been used in cardiology, such as adult somatic cells and endogenous progenitor cells, presenting future perspectives with the use of cardiomyocytes derived from pluripotent stem cells and their extracellular vesicles.