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World J Stem Cells. Aug 26, 2021; 13(8): 1084-1093
Published online Aug 26, 2021. doi: 10.4252/wjsc.v13.i8.1084
Effects of radiation and chemotherapy on adipose stem cells: Implications for use in fat grafting in cancer patients
Rebecca Platoff, Miguel A Villalobos, Ashleigh Rapp Hagaman, Yuan Liu, Martha Matthews, Michael E DiSanto, Jeffrey P Carpenter, Ping Zhang
Rebecca Platoff, Miguel A Villalobos, Ashleigh Rapp Hagaman, Yuan Liu, Martha Matthews, Jeffrey P Carpenter, Ping Zhang, Department of Surgery, Cooper University Health Care, Camden, NJ 08103, United States
Yuan Liu, Martha Matthews, Jeffrey P Carpenter, Ping Zhang, Department of Surgery, Cooper Medical School of Rowan University, Camden, NJ 08103, United States
Michael E DiSanto, Department of Biomedical Sciences, Cooper Medical School of Rowan University, Camden, NJ 08103, United States
Author contributions: Platoff R reviewed the literature and drafted the manuscript; Villalobos MA and Hagaman AR performed the majority of experiments and drafted the manuscript; Liu Y and Matthews M conception and design; DiSanto ME and Carpenter JP critical revision and editing of the manuscript; Zhang P conceived the manuscript, reviewed the literature, performed conception and design, wrote the article and approved the final version as the corresponding author.
Conflict-of-interest statement: The authors declare that there is no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ping Zhang, DDS, PhD, Assistant Professor, Department of Surgery, Cooper University Health Care, 401 Haddon Avenue, Camden, NJ 08103, United States. zhang-ping@cooperhealth.edu
Received: February 25, 2021
Peer-review started: February 25, 2021
First decision: April 20, 2021
Revised: April 30, 2021
Accepted: July 29, 2021
Article in press: July 29, 2021
Published online: August 26, 2021
Processing time: 175 Days and 14.8 Hours
Core Tip

Core Tip: Breast reconstruction with fat grafting after surgery is a major therapy that is enhanced by the use of autologous adipose-derived stem cells (ASCs) following surgery for breast cancer. Emerging studies suggest that cancer treatment therapies have a cytotoxic effect that may limit stem cell cellular functions. In this review, we summarize our work on evaluating the functional recovery potential of autologous ASCs in patients post-radiation or chemotherapy. In addition, we provide evidence that ASCs may represent a novel and effective cellular mechanism for enhancing fat grafting and reconstruction outcomes especially in those patients with cancer.