Review
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Jul 26, 2021; 13(7): 841-860
Published online Jul 26, 2021. doi: 10.4252/wjsc.v13.i7.841
Stem cell therapy: A paradigm shift in breast cancer treatment
Sabiha Khan, Moushumi Suryavanshi, Jasamrit Kaur, Debadatta Nayak, Anil Khurana, Raj Kumar Manchanda, Chanderdeep Tandon, Simran Tandon
Sabiha Khan, Simran Tandon, Amity Institute of Molecular Medicine and Stem Cell Research, Amity University, Noida 201313, Uttar Pradesh, India
Moushumi Suryavanshi, Department of Pathology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi 110085, India
Jasamrit Kaur, Department of Chemistry, Goswami Ganesh Dutta Sanatan Dharma College, Chandigarh 160030, India
Debadatta Nayak, Anil Khurana, Central Council for Research in Homeopathy, New Delhi 110058, India
Raj Kumar Manchanda, Department of AYUSH, Karol Bagh, New Delhi 110011, India
Chanderdeep Tandon, Amity Institute of Biotechnology, Amity University, Noida 201313, Uttar Pradesh, India
Author contributions: All the authors contributed equally towards the concept and structure of the review; the manuscript was written by Khan S under the supervision and guidance of the corresponding author Tandon S; the final draft of the review was reviewed and approved by all the authors.
Supported by Central Council for Research in Homeopathy (CCRH), AYUSH (Govt. of India), No. 17-03/2019-20/CCRH/Tech/Coll/Amity/7284.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Simran Tandon, PhD, Professor, Amity Institute of Molecular Medicine and Stem Cell Research, Amity University, Sector 125, Noida 201313, Uttar Pradesh, India. standon1@amity.edu
Received: February 24, 2021
Peer-review started: February 24, 2021
First decision: April 20, 2021
Revised: April 30, 2021
Accepted: June 17, 2021
Article in press: June 17, 2021
Published online: July 26, 2021
Processing time: 149 Days and 5.5 Hours
Core Tip

Core Tip: Breast cancer is a complex, heterogeneous disease with distinct cancer subtypes, identified through gene expression profiling. The aim of this review is to understand the pathway driven, mechanistic control of breast cancer stem cells and explore the clinical and experimental studies investigating the role of breast cancer stem cells in disease progression. Key factors that are pivotal in breast cancer stem cell growth and their malignant behavior in breast cancer will be elucidated.