Published online Jun 26, 2021. doi: 10.4252/wjsc.v13.i6.659
Peer-review started: February 12, 2021
First decision: March 17, 2021
Revised: March 27, 2021
Accepted: May 27, 2021
Article in press: May 27, 2021
Published online: June 26, 2021
Processing time: 134 Days and 7.7 Hours
Core Tip: Heat shock proteins (HSPs) are housekeeper proteins that guard cells against injury and the damage response. HSPs send signals from diseased or damaged cells to the immune system, which activates the body’s defense system leading to the subsequent release of inflammatory signals that recruit other immune cells and kill the pathogen in case of infection or repair the cells in case of damage. HSPs trigger a cascade of events that involve essential proteins to accelerate the repair process or degrade injured proteins as a protection plan to ensure survival. How HSPs respond to stress or injury stimulus is a question of further investigation. Accumulating evidence indicates that HSP20 is associated with cell proliferation. However, the precise mechanisms by which HSP20 promotes stem cell proliferation remain unclear. Herein, we established the distinct crosstalk between HSP20 and sirtuin 1 in regulating cell proliferation. Our study provides a new avenue for drug discovery and treatment of critical diseases.