Ullah M, Qian NPM, Yannarelli G, Akbar A. Heat shock protein 20 promotes sirtuin 1-dependent cell proliferation in induced pluripotent stem cells . World J Stem Cells 2021; 13(6): 659-669 [PMID: 34249234 DOI: 10.4252/wjsc.v13.i6.659]
Corresponding Author of This Article
Mujib Ullah, MD, PhD, Doctor, Institute for Immunity and Transplantation, Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, 450 Serra Mall, Stanford, CA 94304, United States. ullah@stanford.edu
Research Domain of This Article
Cell Biology
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Stem Cells. Jun 26, 2021; 13(6): 659-669 Published online Jun 26, 2021. doi: 10.4252/wjsc.v13.i6.659
Heat shock protein 20 promotes sirtuin 1-dependent cell proliferation in induced pluripotent stem cells
Mujib Ullah, Nicole Pek Min Qian, Gustavo Yannarelli, Asma Akbar
Mujib Ullah, Institute for Immunity and Transplantation, Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, Stanford, CA 94304, United States
Nicole Pek Min Qian, Immunology and School of Medicine, Stanford University, Stanford, CA 94304, United States
Gustavo Yannarelli, Laboratorio de Regulación Génica y Células Madre, Instituto de Medicina Traslacional, Trasplante y Bioingeniería (IMeTTyB), Universidad Favaloro-CONICET, Buenos Aires 1078, Argentina
Asma Akbar, Institute for Molecular Medicine, School of Medicine, Stanford University, Stanford, CA 94304, United States
Author contributions: Ullah M contributed to the conceptualization, data mining and experiments, coordinated the project, and wrote the paper; Ullah M, Yannarelli G, and Akbar A contributed to the data analyses and writing of the manuscript; Ullah M, Qian NMP, Yannarelli G, and Akbar A analyzed the data and wrote the manuscript, performed the manuscript review, made editing suggestions, and provided final approval; All authors have read and approved the final manuscript.
Institutional review board statement: The study was reviewed and approved by the internal review board of the University Institutional Review Board.
Conflict-of-interest statement: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mujib Ullah, MD, PhD, Doctor, Institute for Immunity and Transplantation, Stem Cell Biology and Regenerative Medicine, School of Medicine, Stanford University, 450 Serra Mall, Stanford, CA 94304, United States. ullah@stanford.edu
Received: February 12, 2021 Peer-review started: February 12, 2021 First decision: March 17, 2021 Revised: March 27, 2021 Accepted: May 27, 2021 Article in press: May 27, 2021 Published online: June 26, 2021 Processing time: 134 Days and 7.7 Hours
Core Tip
Core Tip: Heat shock proteins (HSPs) are housekeeper proteins that guard cells against injury and the damage response. HSPs send signals from diseased or damaged cells to the immune system, which activates the body’s defense system leading to the subsequent release of inflammatory signals that recruit other immune cells and kill the pathogen in case of infection or repair the cells in case of damage. HSPs trigger a cascade of events that involve essential proteins to accelerate the repair process or degrade injured proteins as a protection plan to ensure survival. How HSPs respond to stress or injury stimulus is a question of further investigation. Accumulating evidence indicates that HSP20 is associated with cell proliferation. However, the precise mechanisms by which HSP20 promotes stem cell proliferation remain unclear. Herein, we established the distinct crosstalk between HSP20 and sirtuin 1 in regulating cell proliferation. Our study provides a new avenue for drug discovery and treatment of critical diseases.
