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World J Stem Cells. Jun 26, 2021; 13(6): 605-618
Published online Jun 26, 2021. doi: 10.4252/wjsc.v13.i6.605
Therapeutic potential of periodontal ligament stem cells
Aline Queiroz, Emmanuel Albuquerque-Souza, Leticia Miquelitto Gasparoni, Bruno Nunes de França, Cibele Pelissari, Marília Trierveiler, Marinella Holzhausen
Aline Queiroz, Cibele Pelissari, Marília Trierveiler, Laboratory of Stem Cell Biology in Dentistry-LABITRON, Department of Oral and Maxillofacial Pathology, School of Dentistry, University of São Paulo, São Paulo 05508-000, Brazil
Emmanuel Albuquerque-Souza, Leticia Miquelitto Gasparoni, Bruno Nunes de França, Marinella Holzhausen, Department of Stomatology, Division of Periodontics, School of Dentistry, University of São Paulo, São Paulo 05508-000, Brazil
Author contributions: Queiroz A, Albuquerque-Souza E, Gasparoni LM, França BN, and Pelissari C contributed equally to the study; Albuquerque-Souza E performed the illustration; Trierveiler M and Holzhausen M designed the study; all authors have read and approved the final manuscript.
Conflict-of-interest statement: There is no conflict of interest associated with any author and/or coauthor that contributed to this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Marinella Holzhausen, DDS, MSc, PhD, Academic Research, Professor, Department of Stomatology, Division of Periodontics, School of Dentistry, University of São Paulo, The Butanta district of Sao Paulo, São Paulo 05508-000, Brazil. marinella@usp.br
Received: January 15, 2021
Peer-review started: January 15, 2021
First decision: February 14, 2021
Revised: February 24, 2021
Accepted: April 22, 2021
Article in press: April 22, 2021
Published online: June 26, 2021
Processing time: 161 Days and 12.4 Hours
Core Tip

Core Tip: Periodontal ligament stem cells (PDLSCs) have been studied for their potential to regenerate not only the periodontal complex but also other dental and non-dental tissues. We herein discuss the general features of PDLSCs, and their potential for immunomodulatory, and regenerative therapy.