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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Feb 26, 2021; 13(2): 177-192
Published online Feb 26, 2021. doi: 10.4252/wjSC.v13.i2.177
Published online Feb 26, 2021. doi: 10.4252/wjSC.v13.i2.177
Prior transfusion of umbilical cord mesenchymal stem cells can effectively alleviate symptoms of motion sickness in mice through interleukin 10 secretion
Hua-Su Zhu, Cong Li, Jin-Xian Huang, Shan-Shan Chen, Department of Pediatrics, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong Province, China
Dong Li, Qing Shi, Stem Cell and Regenerative Medicine Research Center, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong Province, China
Lan-Bo Li, Department of Animal Laboratory, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong Province, China
Xiu-Li Ju, Department of Pediatrics, Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China
Author contributions: Zhu HS performed and supervised all the experiments, compiled and analyzed the results, drew the figures, conceived the manuscript, and contributed to all revision phases and writing of the text; Li D conceived the study, designed the experiments, interpreted the results, wrote the discussion, and contributed to the discussion of the draft and revised versions; Li C assisted with the mRNA isolation from animal tissues and gene expression experiments; Huang JX assisted with the Morris water maze experiments; Chen SS was responsible for histological examination and Western blot; Li LB contributed to the collection of blood samples from animals; Zhu HS, Li D, Shi Q, and Ju XL wrote the manuscript; all coauthors have reviewed and agreed the final manuscript.
Supported by Department of Science & Technology of Shandong Province , No. ZR2018MH012 ; Quancheng Industrial Leader Project , No. 2017018 ; and Ji'nan Science and Technology Development Foundation , No. 201704066 .
Institutional review board statement: The study was reviewed and approved by the Ethics Committee on Scientific Research of Shandong University Qilu Hospital.
Institutional animal care and use committee statement: All animal experiments conformed to the internationally accepted principles for the care and use of laboratory animals by the Ethics Committee on Animal Experiment of Shandong University Qilu Hospital (DWLL-2019-023, Shandong, China).
Conflict-of-interest statement: The authors report no conflict of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiu-Li Ju, PhD, Doctor, Department of Pediatrics, Qilu Hospital of Shandong University, No. 107 Wenhua West Road, Jinan 250012, Shandong Province, China. jxlqlyy@163.com
Received: July 31, 2020
Peer-review started: July 31, 2020
First decision: October 21, 2020
Revised: October 31, 2020
Accepted: November 11, 2020
Article in press: November 11, 2020
Published online: February 26, 2021
Processing time: 208 Days and 0.6 Hours
Peer-review started: July 31, 2020
First decision: October 21, 2020
Revised: October 31, 2020
Accepted: November 11, 2020
Article in press: November 11, 2020
Published online: February 26, 2021
Processing time: 208 Days and 0.6 Hours
Core Tip
Core Tip: This study demonstrated that prophylactic transplantation of umbilical cord-derived mesenchymal stem cells (UC-MSCs) can alleviate motion sickness (MS) in mice, particularly at 3-5 d after transplantation. After the MS model was established, molecular biology experiments confirmed the upregulation of interleukin-10 (IL-10) in the cochlea tissues. The transplanted UC-MSCs have activated the JAK2/STAT3 signaling pathway. They reduced the sensitivity of the vestibular cortex to imbalanced movements by secreting IL-10. Accordingly, MSC transplantation is expected to be a new strategy for the prevention and treatment of MS.