Copyright
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Dec 26, 2021; 13(12): 1845-1862
Published online Dec 26, 2021. doi: 10.4252/wjsc.v13.i12.1845
Published online Dec 26, 2021. doi: 10.4252/wjsc.v13.i12.1845
Strategies to improve regenerative potential of mesenchymal stem cells
Mahmood S Choudhery, Department of Biomedical Sciences, King Edward Medical University, Lahore 54000, Punjab, Pakistan
Mahmood S Choudhery, Department of Genetics and Molecular Biology, University of Health Sciences, Lahore 54600, Punjab, Pakistan
Author contributions: Choudhery MS has designed and written the manuscript.
Conflict-of-interest statement: The author declares no conflict of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mahmood S Choudhery, PhD, Associate Professor, Department of Genetics and Molecular Biology, University of Health Sciences, Khayaban-e-Jamia Punjab, Lahore 54600, Punjab, Pakistan. ms20031@yahoo.com
Received: April 18, 2021
Peer-review started: April 18, 2021
First decision: July 18, 2021
Revised: July 31, 2021
Accepted: December 10, 2021
Article in press: December 10, 2021
Published online: December 26, 2021
Peer-review started: April 18, 2021
First decision: July 18, 2021
Revised: July 31, 2021
Accepted: December 10, 2021
Article in press: December 10, 2021
Published online: December 26, 2021
Core Tip
Core Tip: Stem cell-based therapies can treat various diseases and disorders. Mesenchymal stem cells have high self-renewal as well as differentiation potential, however; their potential for cell-based therapies is severely compromised with donor age, disease status and extensive in vitro expansion. Thus autologous use of stem cells isolated from unhealthy, older donors does not seem to give optimal results. It is therefore essential to improve the negative effects of age and disease on resident adult stem cells before clinical use. We herein discuss the strategies such as hypoxia, heat shock, caloric restriction and preconditioning with different factors to enhance the stem cell function.