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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Nov 26, 2021; 13(11): 1797-1812
Published online Nov 26, 2021. doi: 10.4252/wjsc.v13.i11.1797
Published online Nov 26, 2021. doi: 10.4252/wjsc.v13.i11.1797
MKK7-mediated phosphorylation of JNKs regulates the proliferation and apoptosis of human spermatogonial stem cells
Zeng-Hui Huang, Xi-Ren Ji, Wen-Jun Zhou, Xue-Feng Luo, Qian Liu, Yu-Lin Tang, Fei Gong, Wen-Bing Zhu, Institute of Reproductive and Stem Cell Engineering, Central South University, Changsha 410008, Hunan Province, China
Zeng-Hui Huang, Department of Reproductive Center, Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha 410008, Hunan Province, China
Chuan Huang, Department of Sperm Bank, Reproductive and Genetic Hospital of CITIC-Xiangya, Changsha 410008, Hunan Province, China
Author contributions: Zhu WB designed the study and supervised the laboratory experiments; Huang ZH conducted the experiments and drafted the manuscript; Huang C, Ji XR, Zhou WJ and Luo XF assisted with the experiments and sample collection; Liu Q, Tang YL and Gong F performed the analysis with constructive discussion and contributed analysis tools.
Supported by China Postdoctoral Science Foundation , No. 2019M661521 ; and National Natural Science Foundation of China , No. 82001634 .
Institutional review board statement: The Ethics Committee of the Reproductive & Genetic Hospital of CITICXiangya, Basic Medical Science School, Central South University, approved and supervised the present study (Approval No. LL-SC-2020-028).
Conflict-of-interest statement: All authors declared no competing interests.
Data sharing statement: The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding authors.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wen-Bing Zhu, PhD, Professor, Institute of Reproductive and Stem Cell Engineering, Central South University, No. 932 Lushan South Road, Yuelu District, Changsha 410008, Hunan Province, China. zhuwenbing0971@sina.com
Received: July 19, 2021
Peer-review started: July 19, 2021
First decision: August 15, 2021
Revised: August 28, 2021
Accepted: September 15, 2021
Article in press: September 15, 2021
Published online: November 26, 2021
Processing time: 128 Days and 20.3 Hours
Peer-review started: July 19, 2021
First decision: August 15, 2021
Revised: August 28, 2021
Accepted: September 15, 2021
Article in press: September 15, 2021
Published online: November 26, 2021
Processing time: 128 Days and 20.3 Hours
Core Tip
Core Tip: This study demonstrated that mitogen-activated protein kinase kinase 7 regulates the proliferation and apoptosis of human spermatogonial stem cells by mediating the phosphorylation of c-Jun N-terminal kinases in vitro. In addition, we found that mitogen-activated protein kinase kinase 7 was significantly downregulated in patients with reproductive disorders, suggesting that mitogen-activated protein kinase kinase 7 may be associated with human spermatogenesis.