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Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Nov 26, 2021; 13(11): 1647-1666
Published online Nov 26, 2021. doi: 10.4252/wjsc.v13.i11.1647
Epigenetic regulation of dental pulp stem cells and its potential in regenerative endodontics
Ying Liu, Lu Gan, Di-Xin Cui, Si-Han Yu, Yue Pan, Li-Wei Zheng, Mian Wan
Ying Liu, Lu Gan, Di-Xin Cui, Si-Han Yu, Yue Pan, Li-Wei Zheng, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China
Mian Wan, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Liu Y and Wan M conceived the idea and designed the work; Gan L, Cui DX, Yu SH and Pan Y integrated materials; Liu Y wrote the paper; Zheng LW, Wan M revised the manuscript critically; all authors have read and approve the final manuscript.
Supported by National Natural Science Foundation of China, No. 81800929 and No. 81771033; Sichuan Science and Technology Program, No. 2019JDRC0096; and Research and Develop Program, West China Hospital of Stomatology Sichuan University, No. LCYJ2019-24.
Conflict-of-interest statement: The authors declare that there is no conflict of interests regarding the publication of this paper.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mian Wan, DDS, PhD, Academic Fellow, Academic Research, Attending Doctor, Lecturer, Postdoctoral Fellow, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, No. 14 3rd Section of Renmin South Road, Chengdu 610041, Sichuan Province, China. mianwan@scu.edu.cn
Received: February 28, 2021
Peer-review started: February 28, 2021
First decision: May 5, 2021
Revised: June 7, 2021
Accepted: November 2, 2021
Article in press: November 2, 2021
Published online: November 26, 2021
Processing time: 269 Days and 19 Hours
Core Tip

Core Tip: We review the role of epigenetic modifications during fate determination of dental pulp stem cells, highlighting cellular processes implicating proliferation, odontogenesis, angiogenesis, and neurogenesis that are tightly correlated with regenerative endodontics (RE). We emphasize the potential of epigenetic manipulation through enzyme inhibitors in RE and provide insights for future development in regaining dental pulp function.